Histamine release from sensitized leukocytes

Mita, H., Yiu, y., Yasueda, H., Kajita, T., Saito, T. and Shida, T. (1986). Allergen induced histamine released and immunoreactive-leukotriene C4 generation from leukocytes in mite sensitive asthmatic patients. Prostaglandins 31, 869-886. 

Immunologic Two patients with worsening injection site reactions to adalimumab have been described [102 ]. Skin tests suggested immediate type I hypersensitivity reactions. Exposure of peripheral blood leukocytes to adalimumab caused significant histamine release and passive transfer of serum from one of the allergic patients to basophils from a non-atopic, healthy donor sensitized those cells to release significant amounts of histamine after exposure to adalimumab. 

Figure 1. Sequence of events in the secretion of mediators from mast cells or basophil leukocytes. IgE antibody (Y) binds to the cell membrane at specific receptor sites to sensitize the ceU. Antigen cross-linking IgE molecules provide a membrane signal to the cell which sets in motion a chain of biochemical events. The membrane surrounding the granules (%), which contains the mediators, fuses with the cell membrane (exocytosis) to allow the mediators to escape into the surrounding medium. The granule matrix behaves as an ion-exchange resin releasing histamine and taking up Na...

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