Hispanic population

US Census Bureau News (2005) Hispanic population passes 40 million. Washington, DC US Census Bureau, June 9, 2005. 

Smith, M.W., et al., "Markers for Mapping by Admixture Linkage Disequilibrium in African American and Hispanic Populations," Am.. Hum. Genet., 69,1080-1094 (2001). 

Strength Salvation Army provided interpreters for Hispanic population. 

Though crack and powder cocaine are different forms of the same drug, clearly divided ethnic preferences exist. The NHSDA reported in 2000, African Americans are the predominant users of crack, whereas whites are the predominant users of powder cocaine. Socioeconomic status may contribute to this trend. The Hispanic population uses more powder cocaine than crack, but figures overall remain low. 

Another widely studied apo A-IV SNP is an A—>T polymorphism at nucleotide 2346 (first base of codon 347), which causes a threonine-to-serine substitution in the protein product.54-55 The A—>T variant at codon 347 occurs at almost double the frequency of the 360G—>T variant with a prevalence of 22% in Caucasian populations.55-56 However, ethnic differences have been described with lower frequencies in African blacks (9.5%) and Hispanic populations (12.9%).53 The 360G— T and 347A—>T genetic variants are in strong linkage disequilibrium and tend not to occur together.55-57... 

Walss-Bass C, Raventos H, Montero AP, Armas R, Dassori A, et al. 2006b. Association analyses of the neuregulin 1 gene with schizophrenia and manic psychosis in a Hispanic population. Acta Psychiatr Scand 113 314-321. 

Genetics Genetic differences in drug metabolising enzymes may predispose certain patients to hepatotoxicity. For example, the hlack and Hispanic population may he more prone to isoniazid toxicity Genetics may play a role in diclofenac hepatotoxicity... 

Palacio L, et al. Pharmacogenetic Impact of VKORC1 and CYP2C9 Allelic Variants on warfarin dose requirements in a Hispanic population isolate. Clin Appl Thromb Hemost. 2009 16 83-90. 

Alonso et al. (1997) conducted an open-label study of SSRIs in the treatment of depression in 13 Hispanic (Mexican descent) and 13 non-Hispanic female patients. Patients met DSM-III criteria for depression and were treated for 6 weeks with either fluoxetine or paroxetine. Improvement was similar in both groups, but side effects were reported significantly more often by the non-Hispanics. As in many of the clinical studies involving Hispanic populations, the sample size was extremely small. A preponderance of PMs could have been sampled in the non-Hispanic group, which could account for the increased incidence of side effects. As mentioned earlier, the poor-metabolism rate among Caucasians is 5%-10% (Agundez et al. 1994). 

Engle WD, Jackson GL, Sendelbach D, Manning D, Frawley WH. Assessment of a transcutaneous device in the evaluation of neonatal hyperbilirubinemia in a primarily Hispanic population. Pediatrics 2002 110 61-7. 

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