Hippocampus lead accumulation

Brain lead levels had also increased. No accumulation of lead was observed in the lungs, heart, stomach, or spleen over the dosing period. Rat pups (4-8 weeks old) had a 2-3-fold increase in brain lead concentration when oral doses increased by 10-fold from 0.1 to 1 mg lead/kg (Collins et al. 1982). The highest brain lead level in these pups was in the hippocampus. 

Imatinib methanesulfonate salt (IM), known to interfere with the interaction between y-secretase and the y-secretase activating protein (GSAP), decreases the cleavage of peripheral APP into Ap. Because IM poorly penetrates the BBB, co-administration of IM with LPS would decrease peripheral production of Ap in the presence of LPS-induced inflammation, leading to a decrease in Ap accumulation in the hippocampus. Peripheral IM treatment eliminates hippocampal Ap elevation that follows LPS-induced peripheral inflammation [539]. 

Korsching, S., Heumann, R., Thoenen, H. and Hefti, F. (1986) Cholinergic denervation of the rat hippocampus by fimbrial transection leads to a transient accumulation of nerve growth factor (NGF) without change in mRNA content. Neurosci. Lett. 66 175-180. 

Subsequent studies in lead-dosed animals give conflicting evidence concerning the selective accumulation of lead in the hippocampus. Klein and Koch (1981) reported that rats dosed intraperitoneally with 5 and 7.5 mg/kg lead from days 1-10 had more lead in several brain regions than those dosed from days 11-20. The highest concentration was found in the cerebellum, and the lowest in the brain stem and hippocampus, with... 

Several lines of evidence suggest that the hippocampus may be the primary target for lead in the brain. Following the reports that lead preferentially accumulates in the hippocampus (Fjerdingstad et ah, 1974 Danscher ei al, 1976), there are many studies showing morphological alterations after lead... 

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