Hippocampus cell differentiation

Altman J. and Das G.D. (1965) have shown the presence of SC in two departments of rat cerebrum those are the hippocampus and bulbus olfactorius, which can differentiate into three main cell types, astrocytes, oligodendrocytes, and neurons. Afterwards, analogous cells were obtained from subventricular and ventricular parts of cerebrum. 

The adult hippocampus also contains progenitors/ stem cells that are capable of differentiating into new hippocampal granule neurons. Hippocampal progenitor cells will give rise to new neurons in adult rodent, primate, and human brains (Eriksson et ah, 1998). The new hippocampal granule cells extend axons that are appropriately connected to the pyramidal cells in the CAS region. 

Adult-derived neural progenitor and stem cells have been transplanted into the CNS of normal and animal models in rodents. Adult rat hippocampal-derived neural progenitor and stem cells have been grafted into the hippocampus, where they differentiated into neuronal and glial cells [12]. In another study, adult rat spinal-cord-derived neural progenitor and stem... 

Nishida, A., Takahashi, M., Tanihara, H., Nakano, I., Takahashi, J.B., Mizoguchi, A., Ide, C., Honda, Y. (2000). Incorporation and differentiation of hippocampus-derived neural stem cells transplanted in injured adult rat retina. Invest Ophthalmol Vis Sci, 41, 4268-74. 

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Kornack DR, Rakic P (1999) Continuation of neurogenesis in the hippocampus of the adult macaque monkey. Proc Natl Acad Sci USA 96 5768-5773 Kornack DR, Rakic P (2001a) The generation, migration, and differentiation of olfactory neurons in the adult primate brain. Proc Nad Acad Sci USA 98 4752-4757 Kornack DR, Rakic P (2001b) Cell proliferation without neurogenesis in adult primate neocortex. Science 294 2127-2130... 

Barco A, Alarcon JM, Kandel ER (2002) Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108 689-703 Bear MF, Malenka RC (1994) Synaptic plasticity LTP and LTD. Curr Opin Neurobiol 4 389-99 Bender RA, Brewster A, Santoro B, Ludwig A, Hofmann F, Biel M, Baram TZ (2001) Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1 1 suggests evolving roles in the developing rat hippocampus. Neuroscience 106 689-98... 

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