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High-Throughput Measurement of Physicochemical Properties

Absorption, distribution, metabolism, and excretion Blood-brain barrier Bovine serum albumin [Pg.101]

Human colon adenocarcinoma cell line used as a permeation/ absorption model [Pg.101]

Chromatography hydrophobicity index Dimethyl sulfoxide Fetal calf serum [Pg.101]

High-throughput screening Madin-Darby canine kidney Molecular weight [Pg.101]

Parallel artificial membrane permeability assay Phosphate buffered saline [Pg.101]

Kerns EH (2001) High Throughput Physicochemical Profiling for Drug Discovery. J Pharm Sci 90(11) 1838-1858 Kibbey CE, Poole SK, Robinson B et al. (2001) An Integrated Process for Measuring The Physicochemical Properties of Drug Candidates in a Preclinical Discovery Environment. J Pharm Sci 90(8) 1164-1175... [Pg.399]

Valko K. Measurements and predictions of physicochemical properties. High-Throughput ADMETox Estimation 2002 1-24 A1-A5. [Pg.139]

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High-throughput

Measurements of properties

Physicochemical high-throughput measurement

Physicochemical measurements

Physicochemical propertie

Physicochemical properties of

Physicochemical property

Properties measured