High-throughput fragment-based

Our Approach to High-Throughput Fragment-Based Docking... 

Figure 17.2 Low micromolar inhibitors discovered by high-throughput fragment-based docking into 3-secretase (compounds 1 and 2), plasmepsin II (3), West Nile virus NS3 protease (4 and S),cathepsin B (6), EphB4tyrosine kinase...

Dihydroneopterin aldolase (Table 1, entry 8) Inhibitors (such as 33) of dihydro-neopterin aldolase were identified using high throughput X-ray-based fragment screening of a 10,000 member random library [43]. Structure-guided optimisation gave potent leads such as 35. 

J. M. Blaney, V. Nienaber and S. K. Burley, Fragment-based lead discovery and optimization using X-ray crystallography, computational chemistry, and high throughput organic synthesis, in... 

Huth, J.R., Sun, C. Utility of NMR in lead optimization fragment-based approaches. Comb. Chem. High. Throughput Screen. 2002, 5, 631-643. 

Baskin, I. Varnek, A. Building a chemical space based on fragment descriptors. Comb. Chem. High Throughput Screening 2008, 11 (8), 661-668. 

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