High-throughput catalyst testing

Hendershot, R.J., Lasko, S.S., Fellmann, M.-F. et al. (2003) A novel reactor system for high throughput catalyst testing under realistic conditions. Appl. Catal. A Gen., 254, 107. 

Dimethyl itaconate was reduced by hydrogen transfer from aqueous sodium formate under mild conditions (Scheme 3.29). This reaction served also as one of the model processes in development of new reactors, such as the centrifugal partition chromatograph, for high throughput catalyst testing [246-248],... 

Richter, A., Langpape, M., Kolf, S. et al. (2002) Combinatorial preparation and high-throughput catalytic tests of multi-component deNO(x) catalysts. Appl. Catal. B Environ., 36, 261. 

J.C. Vedrine, E.G. Derouane, in Combinatorial Catalysis and High Throughput Catalyst Design and Testing, E.G. Derouane, F. Lemos, A. Corma, F.R. Ribeiro (Eds.), Kluwer Academic Publishers, 2000, p. 125. 

In the same publication, a method for the parallelization of TAP experiments was also indicated. It was stated that ...high-throughput transient kinetics carried out in addition to high-throughput catalyst synthesis and testing both accelerate the search for new catalytic materials and bring fundamental insights into reaction mechanisms. ... 

Derouane EG, Lemos F, Corma A, Ramoa F, Eds. Rostrup-Nielsen JR, Scale-up of catalytic processes, Combinatorial Catalysis and High Throughput Catalyst Design and Testing, 337-361, Ed. Kluwer Academic Publishers, The Netherlands, 2000. 

The implementation of combinatorial chemistry and automated methods for rapid synthesis, testing, and characterization of catalysts, has opened a wide range of new opportunities in catalysis. However, so far, Mossbauer spectroscopy has not been introduced into this methodology. Two hurdles must be overcome for Mossbauer spectroscopy to become important in high-throughput catalyst characterization the system for recording spectra must be scaled down, and the data acquisition and exploitation systems must be adapted. 

For the search of new more-thioresistant catalysts for low-temperature isomerisation of light paraffins, combinatorial techniques (high-throughput catalyst preparation and testing, and a GA) were used. After three iterative cycles (generations) catalysts have been found that were not only active and selective but also more resistant to deactivation by water and sulphur than the corresponding conventional ones. The results were reproducible in a pilot plant. 

Senkan, S., Krantz, K., Ozturk, S. et al. (1999) High-throughput testing of heterogeneous catalyst libraries using array microreactors and mass spectrometry. Angew. Chem. Int. Ed., 38, 2794. 

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