High-speed chemistry

Larhed, M. and Hallberg, A., Microwave-assisted high-speed chemistry a new technique in drug discovery, Drug Discov. Today, 2001, 6, 406-416. 

The ability to assess dmg-likeness is even more important in the design of libraries made using high-speed chemistry. If library design is driven primarily by the ease-of-synthesis and stmctural diversity of an array of compounds, it... 

High-Speed Chemistry Libraries Assessment of Drug-Likeness 149... 

The issues chemists deal with during lead optimization are the same that contribute to general drug-likeness the need to reduce toxicity or to improve solubility, oral absorption, blood-brain barrier penetration and metabolic stability. Computational methods that can directly predict these properties of compounds would allow for the design of high-speed chemistry libraries which are instrumental in solving these specific needs. 

Larhed M, Hallberg A (2001) Microwave-assisted high-speed chemistry, a new technique... 

Interestingly, the procedure of hydroxycarbonylation by using lithium formate and acetic anhydride as internal condensed sources of carbon monoxide can be carried out in the presence of a recoverable and reusable phosphine-free palladium-carbon aerogel catalyst [61]. To support high-speed chemistry and automated organic synthesis, an operationally simple and environmentally safe hydroxycarbonylation of vinyl triflates can... 

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