Multidimensional high-performance liquid chromatography

C. G. Chappell, C. S. Creaser and M. J. Shepherd, On-line high performance liquid chromatography-multidimensional gas chromatography and its application to the determination of stilbene hormones in corned beef , J. High Resolut. Chromatogr. 16 479-482(1993). 

A. J. Szuna and R. W. Blain, Determination of a new antibacterial agent (Ro 23-9424) by multidimensional high-performance liquid chromatography with ulti aviolet detection and direct plasma injection , 7. Chromatogr. 620 211-216 (1993). 

MDHPLC Multidimensional high-performance liquid chromatography... 

Shalliker, R. A., Gray, M.J. (2006). In Grushka, E., Grinberg, N., editors. Concepts and Practice of Multidimensional High-Performance Liquid Chromatography Advances in Chromatography, Vol. 44. Taylor and Francis Group, New York. 

Valentine, S.J., Kulchania, M., Srebalus Barnes, C.A., Clemmer, D.E. (2001). Multidimensional separations of complex peptide mixtures a combined high-performance liquid chromatography/ion mobility/time-of-flight mass spectrometry approach. Int. J. Mass. Spectrom. 212, 97. 

Majors, R.E. (1980). Multidimensional high performance liquid chromatography. J. Chromatogr. Sci. 18(10), 571-579. 

Issaq, H.J., Chan, K.C., Cheng, S.L., Qingho, L. (2001). Multidimensional high performance liquid chromatography-capillary electrophoresis separation of a protein digest an update. Electrophoresis 22, 1133-1135. 

H. J. Cortes and L. D. Rothman, Multidimensional high-performance liquid chromatography in Multidimensional Chromatography Techniques and Applications, H. J. Cortes (Ed.) Marcel Dekker, New York, Ch. 6, pp. 219-250 (1990). 

Figure 10.9 Chromatograms of fortified coconut oil obtained by using (a) normal-phase HPLC and (b) GPC/normal-phase HPLC. Peak identification is as follows 1 (a,b), DL-a-toco-pheryl acetate, 2 (b), 2,6-di-terf-butyl-4-methylphenol 2 (a) and 3 (b), retinyl acetate 3 (a) and 4 (b), tocol 4 (a) and 5 (b), ergocalciferol. Reprinted from Analytical Chemistry, 60, J. M. Brown-Thomas et al., Determination of fat-soluble vitamins in oil matrices by multidimensional high-performance liquid chromatography , pp. 1929-1933, copyright 1988, with permission from the American Chemical Society.

J. M. Brown-Thomas, A. A. Moustafa, S. A. Wise and W. E. May, Determination of fat-soluble vitamins in oil matrices by multidimensional high-performance liquid chromatography , Anal. Chem. 60 1929-1933 (1988). 

D. Wu, M. Berna, G. Maier and J. Johnson, An automated multidimensional screening approach for rapid method development in high-performance liquid chromatography , J. Pharm. Biomed. Anal. 16 57-68 (1997). 

Figure 15.3 Separation of tricyclic antidepressants by using multidimensional LC-LC. Peak identification is as follows DOX, doxepin DES, desipramine NOR, nortryptylene IMI, imipramine AMI, amitryptyline. Adapted from Journal of Chromatography, 507, J. V. Posluszny et al., Optimization of multidimensional high-performance liquid chromatography for the determination of drugs in plasma by direct injection, micellar cleanup and photodiode array detection , pp. 267-276, copyright 1990, with permission from Elsevier Science.

Figure 15.5 Separation of Voriconazole and an internal standard by using SEC-HPLC. Adapted from Journal of Chromatography, B 691, D.A. Stopher and R. Gage, Determination of a new antifungal agent, voriconazole, by multidimensional high-performance liquid chromatography with direct plasma injection onto a size exclusion column , pp. 441 -448, copyright 1997, with permission from Elsevier Science.

Whelan, T. J., Shalliker, R. A., McIntyre, C., and Wilson, M. A. (2005). Development of a multidimensional high-performance liquid chromatography (HPLC) separation for bayer humic substances. Ind. Eng. Chem. Res. 44,3229-3237. 

---