Hexyl Hydrochlorid

Place 80 g, of hydroxylamine sulphate (or 68-5 g. of the hydrochloride), 25 g. of hydrated sodium acetate, and 100 ml. of water in a 500 ml. flask fitted with a stirrer and a reflux water-condenser, and heat the stirred solution to 55-60°. Run in 35 g (42 nil,) of -hexyl methyl ketone, and continue the heating and vigorous stirring for ij hours. (The mixture can conveniently be set aside overnight after this stage.) Extract the oily oxime from the cold mixture twice with ether. Wash the united ethereal extract once with a small quantity of water, and dry it with sodium sulphate. Then distil off the ether from the filtered extract, preferably using a distillation flask of type shown in Fig. 41 (p. 65) and of ca, 50 ml, capacity, the extract being run in as fast as the ether distils, and then fractionally distil the oxime at water-pump pressure. Collect the liquid ketoxime, b.p. 110-111713 mm. Yield, 30-32 g. 

Cyclohexylurea has been prepared by the reaction of cyclo-hexyl isocyanate with gaseous ammonia or ammonium hydroxide, by thermal decomposition of cyclohexyl allophanamide, by treating cyclohexylamine hydrochloride with an aqueous solution of potassium cyanate," by heating nitrosomethylurea with cyclohexylamine, and by heating an ethanolic solution of cyclohexylamine and 3,5-dimethyl-l-carbamylpyrazole. 2,6-DimethyIphenyIthiourea has been synthesized by allowing 2,6-dimethylaniline hydrochloride to react with ammonium thiocyanate. ... 

Currently available BAS include cholestyramine, colestipol and colesevelam hydrochloride (colestimide). Cholestyramine comprises a long-chain polymer of styrene with divinylbenzene trimethylbenzylammonium groups, whereas colestipol is a long-chain polymer of l-chloro-2,3-epoxypropane with diethylenetriamine. Colesevelam HCl is poly(allylamine hydrochloride) cross-linked with epichlorohydrin and alkylated with 1-bromodecane and 6-bromo-hexyl-trimethylammonium bromide. Bile-acid binding is enhanced and stabilised in the latter compound by long hydrophobic sidechains, increased density of primary amines, and quaternary amine sidechains. For this reason, colesevelam HCl exhibits increased affinity, specificity and capacity to bind bile acids compared with the other BAS. Colesevelam HCl also binds dihydroxy and trihydroxy bile acids with equal affinity, contrasting with cholestyramine and colestipol that preferentially bind dihydroxy bile acids (CDCA and deoxycholic acid). The latter BAS can lead to an imbalance towards trihydroxy bile acids and a more hydrophilic bile-acid pool. 

To a solution of 13.6 g (0.08 mol) of N-hexylpiperazine and 8.1 g (11.2 ml), (0.08 mol) of triethylamine in 120 ml toluene, was added 15.6 g (0.08 mol) of N-isobutyl-benzimidoyl chloride over a period of 15 minutes. The reaction mixture was stirred at room temperature for a period of 2 hours. The triethylamine hydrochloride was filtered off and the filtrate concentrated under vacuum. The residual oily base was washed with 20 ml water, extracted with 50 ml ether and dried over anhydrous magnesium sulfate. The dry ethereal solution was then added to a solution of 18.6 g (0.16 mol) maleic acid in 800 ml ether to obtain the dimaleate salt. Two recrystallizations from ethanol yielded 22.5 g (50.2%) of N-[(4-hexyl-l-piperazinyl)phenylmethylene]-2-methyl-l-propanamine product, M.P. 175°-176°C. 

Dehydrogenation of 1-methyl-1-azacyclooctane (28) with mercuric acetate, followed by treatment with hydrogen sulfide and hydrochloric acid, gave the hydrochloride of 2,4,6-tris-(6-methylamino-hexyl)trithiane (29) only.48 Analogous compounds have been obtained... 

Hexonium bromide, 654 Hexonium iodide, 654 Hexopal, 683 Hexoprenaline, 658 Hexoprenaline hydrochloride, 658 Hexoprenaline sulphate, 658 Hexoral, 655 Hextril, 655 Hexyl nicotinate, 658 Hexylbenzenediol, 659... 

Figure 4-24. Benazepril hydrochloride SS and SR isomers on Phenomenex phenyl-hexyl column, 150 x 4.6 mm, 70% ammonium phosphate buffer (wpH 2.1-7.1), 30 v/v% MeCN, ImL/min, 25°C. (Courtesy of Rajinder Singh.)...

Poly[V-(3-aminopropyl)methylacrylamide hydrochloride] Poly(sodium-2-acrylamido-2-methylpropanesulfonate) Poly 6-[4-(4-methylphenyl-azo) phenoxy]hexyl acrylate Poly(butadiene)... 

Diethylamino) ethyl [bicyclohexyl]-1-carboxylate hydrochloride Bicyclo-hexyl]-l-carboxylic acid, 2-(diethylamino) ethyl ester, hydrochloride BP USP ... 

Potassium hydroxide Potassium chloride Methylene blue Desogren Geisry Barium chloride Benzidine hydrochloride Ferric chloride Phosphotunsrstic acid Tannic acid Ruthenium re l Thorium nitrate Hexyl nitrate... 

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