Hexa cyclohexyl

Treatment of 2-benzoyl-l,2,3,6,7,l lh-hexahydro-4//-pyrazino[2,l-a]-isoquinolin-4-one with NaNH2, then with ethylene oxide yielded the 3-(2-hydroxyethyl) derivative (76GEP2441261). 4-Thioxo and 2-(cyclohexyl-thiocarbonyl)-4-thioxo derivatives were prepared from 1,2,3,6,7,116-hexa-hydro-4//-pyrazino[2,l-a]isoquinolin-4-one and its 2-cyclohexylcarbonyl derivative by treatment with P4Si0. 

On the other hand, in penta- and hexa(spirotetrahydrofuranyl)cyclohexyl systems the chair conformation of the central cyclohexane ring is still preserved (96JA4504). The boat conformation of the cyclohexane ring can be stabilized also by careful substitution. A series of hopanoid hydrocarbons, the D cyclohexane ring prefers the boat conformation by 1.3-2.5 kcal/mol (95JA6532). 

Cyclohexanol Adronal Anol Cyclohexyl Alcohol Hexalin Hexa hydrophenol... 

R = nPr, iPr, cyclohexyl, cyclopentyl, fBu, Ph-C=C) to form heterocyclic enamines 27 which, after acid-catalyzed removal of the chiral C2-symmetrical amine, yielded the hexa-hydropyridazines 28 (six examples) with an ee of 90-91 %. The successful use of another chiral amine, [(5,5 )-3,5-dimethylmorpholine], gives further indication of the efficiency of asymmetric induction by means of coupling at the C-2 position of the diene. 

In order to accomplish catalytic arylations of inert secondary alkyl chlorides, Fu and coworkers have developed highly active nickel catalysts, consisting of a nickel halide and a P-aminoalcohol. The cross-coupling between cyclohexyl chloride and phenylboronic acid, thus, takes place smoothly in the presence of a catalytic amount of [NiCl2dme] and (S)-(-t-)-proUnol, along with 2 equiv. of potassium hexa-methyldisilazide (KHMDS), to provide cyclohexylbenzene in 80% yield (Equation 5.21) [26]. 

Nitrosoureas such as 1,3-bls (2-chloroethyl)-1-nitrosourea (BCNU) and l-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) have shown significant activiiy in a wide spectrum of animal and human neoplasms 97-99 Qf particular value is their ability to penetrate the blood-brain barrier. These compounds appear to act by allqrlatlon of nucleic acids and/or by cyclohejqrlcarbamoylation of the lysine residues of proteins . 3-(Tetraacetyl glucopyranos-2-yl)-l-(2-chloroethyl)-l-nitrosourea (GCNU) (XI), which is structurally related to streptozotodn, is markedly active against leukemia L-1210, without the marked bone marrow toxicity exhibited by BCNU or CCNU . Marked inhibition of L-1210 growth has also been reported for 1,1 -ethylenebis (1-nitrosourea) and for the hexa-methylene derivative. ... 

---