Heterotopic bone

Fig. 5 Effect of transforming growth factor-/ (hTGF-/9) isoforms on key parameters of heterotopic bone formation by induction on day 30 and 90.

Gene feerapy and cell therapy have been combined to result in murine stromal cells transduced to produce Bh4P-2. The cells were seeded on a PLGA-HA matrix and found to induce heterotopic bone regeneration (Laurencin et al., 2001). Likewise, rat dermal cells were infected with a retrovirus... 

Eidil M et al (2012) Heterotopic bone formation following anterior cruciate ligament reconstruction with BPTB autograft. Acta Orthop Traumatol Turc 46(l) 72-76... 

Miyazawa, K., Kawai, T, and Urist, M.R., Bone morphogenetic protein-induced heterotopic bone in osteopetrosis, Clin. Orthop. Relat. Res. 324,259,1996. 

Muscle tears can be followed by cystic transformation of the hematoma consisting of an ovoid fluid-filled anechoic cavity with well-defined margins located within the muscle (Fig. 13.28). A significant complication of vastus intermedius tears secondary to direct contusion trauma is myositis ossificans circumscripta, which is also referred to as heterotopic bone formation. This self-limiting condition starts with undefined chronic pain in the middle thigh... 

Winter, G.D., Simpson, B.J., 1969. Heterotopic bone formed in a synthetic sponge in the skin of young pigs. Nature 223, 88-90. 

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