Herpes simplex virus infection ganciclovir

Foscamet is used i.v. for retinitis due to CMV in patients with HIV infection when ganciclovir is contraindicated it has also been used to treat aciclovir-resistant herpes simplex virus infection (see p. 258). It causes numerous adverse effects, including renal toxicity, nausea and vomiting, neurological reactions and marrow suppression. 

Cidofovir is an acyclic nucleotide analogue of the monophosphate of cytosine. When phosphorylated by host cellular enzymes, the active compound cidofovir diphosphate has broad activity against the herpes viruses, including CMV, herpes simplex viruses 1 and 2, varicella zoster virus and Epstein-Barr virus. Cidofovir is used primarily in treatment of CMV retinitis in patients who have failed treatment with ganciclovir or foscamet and in acyclovir-resistant herpes simplex infections. 

Foscamet is an antiviral agent that inhibits replication of all known herpes viruses, including cytomegalovirus (CMV), herpes simplex virus types 1 and 2 (HSV-1, HSV-2), human herpes virus 6 (HHV-6), Epstein-Barr virus (EBV) and varicella-zoster virus (VZV). It is indicated in the treatment of CMV retinitis in patients with AIDS treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients and as combination therapy with ganciclovir for patients who have relapsed after monotherapy with either drug. 

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