HER-2 c-erbB-2 Oncoprotein

HER-2/nen gene was first discovered as a transforming oncogene in a series of ethyl nitrosourea-induced rat neuroblastomas, where it was called neu (Schecter et al., 1984). Approximately 15 years ago, this oncogene was isolated independently by two separate groups, which named it HER-2 (Coussens et al., 1985) and c-erbB-2 (Semba et al., 1985), respectively. Further evidence revealed that the two genes were the same (Schechter et al., 1985), and it was renamed HER-2Ineu. 

The HER-2/neM gene is also overexpressed in epithelial ovarian cancer. Several studies have reported that overexpression of this gene is associated with poor survival rates in 

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