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Heptasaccharide phytoalexin elicitor

In 1997 Nicolaou et al. published the assembly of a heptasaccharide phytoalexin elicitor (HPE, 16) on a solid support (Schemes 5.2-5.4).29 This oligosaccharide... [Pg.102]

Scheme 5.4 Photolytic cleavage of resin-bound heptasaccharide 15 and deprotection to yield the heptasaccharide phytoalexin elicitor 16.29... Scheme 5.4 Photolytic cleavage of resin-bound heptasaccharide 15 and deprotection to yield the heptasaccharide phytoalexin elicitor 16.29...
Nicolau, K. C., Winssinger, N., Pastor, J., and DeRoose, F. (1997) A general and highly efficient solid phase synthesis of oligosaccharides. Total synthesis of a heptasaccharide phytoalexin elicitor (HPE)../. Am. Chem. Soc. 119,449—450. [Pg.244]

The addition of a second, reducing end acceptor and a thiophilic promoter (NIS) resulted in trisaccharide formation. Yields as high as 84% for the overall process were reahzed, showcasing the efficiency of this strategy as well as the promoter compatibility, which can be a problem (Fig. 3). The method has been extended to branched structures as well (34). Takahashi has advanced the orthogonal OPG strategy in an impressive synthesis of the heptasaccharide phytoalexin elicitor (HPE) in 24% overall yield (35). [Pg.620]

The second example is a solid-phase synthesis of a heptasaccharide phytoalexin elicitor. Here, attachment of the polymer was to the reducing end of the oligosaccharide. The structure was chosen as an example for the development of... [Pg.106]

Scheme 4.21 Mukaiyama s one-pot synthesis of phytoalexin-elicitor active heptasaccharide. Scheme 4.21 Mukaiyama s one-pot synthesis of phytoalexin-elicitor active heptasaccharide.
P. FOgedi, W. Birberg, P. J. Garegg, and A. Pilotti, Synthesis of a branched heptasaccharide having phytoalexin-elicitor activity, Carbokydr. Res 164 797 (1987). [Pg.68]

The glucoheptaose 13, which has phytoalexin elicitor activity, has been prepared using a polymer- supported solution synthesis. Compound 14 with A/-phthaloylation was made as a fully substituted glycosyl azide in work associated with tumour-related A -bonded glycans, and related work on glycoprotein led to the preparation of the xylose-containing heptasaccharide 15. ... [Pg.75]

This octopus concept is impressive in that a large number of glycosylated branches are created in one reaction but this strategy was found difficult to continue at the next level due to steric hindrance and moderate yields in per-allylation and per-hydroboration. As a consequence a convergent approach have been preferred in larger constructions. Colonna et al. have described the preparation of a dendrimer with three heptasaccharide elements which was inspired by Polotti s work on the synthesis of the phytoalexin elicitor analogues. ... [Pg.283]

As an exact analog of the phytoalexin elicitor branched heptasaccharide 82 the branched SPH 83 was devised with four amide bonds replacing the 1 -> 6 linkages of the pentasaccharide backbone and thus producing the same length. No elicitor activity was detected for 83, possibly because of the reduced flexibility or different conformation of the mimetic structure [56]. Mimetics of the sialyl Lewis and sialyl Lewis oligosaccharides have recently foimd increased attention. Baisch and... [Pg.581]

The glucose heptamer 22, which has been synthesized, is a phytoalexin elicitor of soya beans, and compound 23, which is the heptasaccharide moiety of ganglioside BGMj has been prepared as the methyl ester of the neuraminic acid moiety." Compound 24 has been prepared and in the form of its glycosylamine linked to a pentapeptide to give a product which represents a unit of ovalbumin." ... [Pg.71]


See other pages where Heptasaccharide phytoalexin elicitor is mentioned: [Pg.104]    [Pg.622]    [Pg.17]    [Pg.17]    [Pg.86]    [Pg.115]    [Pg.1798]    [Pg.1832]    [Pg.104]    [Pg.622]    [Pg.17]    [Pg.17]    [Pg.86]    [Pg.115]    [Pg.1798]    [Pg.1832]    [Pg.230]    [Pg.369]    [Pg.181]    [Pg.498]   


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Elicitor

Heptasaccharide

Heptasaccharides

Phytoalexin

Phytoalexine

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