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Hepoxilins

As far as the biological action in Aplysia neurons of hepoxilin A3 and 12-kete is concerned, application of hepoxilin A3 to L14 neurons results in a marked membrane hyperpolarization, accompanied by an increased membrane ion conductance, while application of 12-kete to the same cells produced... [Pg.88]

Hepoxilin hydrolase (EC 3.3.2.7), which converts hepoxilin A3 to trioxi-lin A3. [Pg.614]

The autacoids comprise histamine, serotonin, angiotensin, neurotensin, NO (nitric oxide), kinins, platelet-activating factor, endothelins and the four families of traditional eicosanoids - the leukotrienes and three types of prostanoids i.e. prostaglandins, prostacyclins, and thromboxanes. Several other natural occurring molecules are sometimes called eicos-anoid, including the hepoxilins, resolvins, isofurans, isoprostanes, lipoxins, epoxyeicosatrienoic acids (EETs) and some endocannabinoids. However, not... [Pg.311]

Mrsny, R.J., et al. 2004. Identification of hepoxilin A3 in inflammatory events A required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci 101 7421. [Pg.34]

P. Demin, D. Reynaud, and C. R. Pace-Asciak, High-performance liquid chromatographic separation of fluorescent esters of Hepoxilin enantiomers on a chiral stationary phase, / Chromatogr. B 672 (1995), 282-289. [Pg.260]

Aryldihydropyrimidincs Fluorescent esters of hepoxilins Fluorenone-1,4-dihydropyridine derivalis cs Fluoxetine... [Pg.365]

Laneuville, O., Couture, R. and Paceasciak, C.R. (1992). Neurokinin A-induced contraction of guinea-pig isolated trachea - potentiation by hepoxilins. Br. J. Pharmacol. 107, 808-812. [Pg.142]

The classical Simmons-Smith reagent was used to cyclopropanate a double bond in the presence of a triple bond in the synthesis of racemic 11,12-cyclopropyl analogs of hepoxilins Aj and ( )-Undec-2-en-5-ynol (4) was treated with diiodomethane/zinc-copper couple in anhydrous diethyl ether to afford the intermediate racemic (lS, 2S )-l-hydroxymethyl-2-... [Pg.265]

Hepoxilins are monohydroxy-epoxide derivatives of arachidonic acid that release intracellular calcium and open potassium channels. Hepoxilins appear to have proin-flammatory actions in the skin, but inhibit the actions of inflammatory agents in the human neutrophil. Hepoxifin... [Pg.322]

EpETrEsepoxyeicosatrienoic acids (Di)HETE=(di)hydroxyei-cosatetraenoic acids HpETEshydroperoxyeicosatetiaenoic acids DiHETrE dihydroxyeicosatrienoic acids LX=lipoxins PGUprostacyclins TX thromboxanes LT=leukotrienes PQsprostaglandins Hx=hepoxilins PGG, PGH=prostaglandin endoperoxides... [Pg.49]

Fig. 2. Hematoxylin and eosin stain of lung sections from mice receiving intratracheal saline (Panel A, control) or bleomycin (BL, Panels B and C). All mice also received either intraperitoneal saline (Panels A and B) or the hepoxilin analog, PBT-1 (Panel C) at the dose indicated. Note in Panel B the massive alveolar hemorrhage and edema that are controlled by PBT-1 (Panel C). Fig. 2. Hematoxylin and eosin stain of lung sections from mice receiving intratracheal saline (Panel A, control) or bleomycin (BL, Panels B and C). All mice also received either intraperitoneal saline (Panels A and B) or the hepoxilin analog, PBT-1 (Panel C) at the dose indicated. Note in Panel B the massive alveolar hemorrhage and edema that are controlled by PBT-1 (Panel C).
Demin, P.M., Kochev, DM., Perrier, H., Pace-Asciak, CR., and Pivnitsky, K.K. (1997) Synthesis of a Photoaffinic Hepoxilin Analog, Mendeleev Commun. 1-2. [Pg.259]

Reynaud, D., Demin, R, and Pace-Asciak, C.R. (1996) Hepoxilin Aj-Specific Binding in Human Neutrophils, Biochem. J.313, 537-541. [Pg.259]

Jankov, R.R, Luo, X., Demin, R, Aslam, R., Hannam, V., Tan-swell, A.K., and Pace-Asciak, CR. (2002) Hepoxilin Analogs Inhibit Bleomycin-Induced Pulmonary Fibrosis in the Mouse, J. Pharmacol. Exp. Ther. 301,435-440. [Pg.259]

See other pages where Hepoxilins is mentioned: [Pg.88]    [Pg.169]    [Pg.400]    [Pg.143]    [Pg.949]    [Pg.949]    [Pg.24]    [Pg.158]    [Pg.141]    [Pg.353]    [Pg.322]    [Pg.305]    [Pg.217]    [Pg.217]    [Pg.287]    [Pg.287]    [Pg.299]    [Pg.256]    [Pg.256]    [Pg.256]    [Pg.256]    [Pg.256]    [Pg.257]    [Pg.258]   
See also in sourсe #XX -- [ Pg.9 , Pg.577 ]

See also in sourсe #XX -- [ Pg.322 ]

See also in sourсe #XX -- [ Pg.9 , Pg.577 ]

See also in sourсe #XX -- [ Pg.531 ]

See also in sourсe #XX -- [ Pg.11 , Pg.81 , Pg.111 , Pg.120 , Pg.141 ]



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Hepoxilin

Hepoxilin hydrolase

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