Hepatocarcinogenesis effects

Ohnishi H, Asamoto M, Tujimura K, Hokaiwado N, Takahashi S, Ogawa K, et al. Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo. Cancer Sci 2004 95 936-42. 

Sugie S, Okumura A, Tanaka T and Mori H. 1993. Inhibitory effects of benzylisothiocyanate and ben-zylthiocyanate on diethylnitrosamine-induced hepatocarcinogenesis in rats. Jpn J Cancer Res 84 865— 870. 

Tanaka T, Mori Y, Morishita Y, Hara A, Ohno T, Kojinna T and Mori H. 1990. Inhibitory effect of sinigrin and indole-3-carbinol on diethylenitrosamine-induced hepatocarcinogenesis in male AC/N rats. Carcinogenesis 11 1403—1406. 

Moreno FS, S-Wu T, Naves MM, Silveira ER, Oloris SC, Costa MA, Dagli ML and Ong TP. 2002. Inhibitory effects of beta-carotene and vitamin A during progression phase of hepatocarcinogenesis involve inhibition of cell proliferation but not alterations in DNA methylation. Nutr Cancer 44 80-... 

Sampaio ARD, Chagas CEA, Ong TP and Moreno FS. 2007. Vitamin A and 3-carotene inhibitory effect during 1,2-dimethylhydrazine induced hepatocarcinogenesis potentiated by 5-azacytidine. Food Chem... 

Guyonnet D, Berges R, Siess MH, Pinnert ME, Chagnon MC, Suschetet M, Le Bon AM. (2004) Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis. Food Chem Toxicol 42 1479-1485. 

Dragiani TA, Manenti G, Porta GD. 1986. Enhancing effects of carbon tetrachloride in mouse hepatocarcinogenesis. Cancer Lett 31 171-179. 

Zalatnai A, Sarosi I, Rot A, et al. 1991. Inhibitory and promoting effects of carbon tetrachloride-induced liver cirrhosis on the diethyinitrosamine hepatocarcinogenesis in rats. Cancer Lett 57 67- 73. 

Ashby, J. Clapp, M.J.L. (1995) The rodent dominant lethal assay a proposed format for data presentation that alerts to psendo-dominant lethal effects. Mutat. Res., 330, 209-218 Ashby, J., Brady, A., Elcombe, C.R., Elliott, B.M., Ishmael, J., Odnm, J., Tngwood, J.D., Kettle, S. Purchase, IF. (1994) Mechanistically-based human hazard assessment of peroxisome proliferator-induced hepatocarcinogenesis. Hum. exp. Toxicol., 13 (Suppl. 2), S1-S117... 

Rodent peroxisome proliferators exercise their pleiotropic effects due to activation of PPARa. This process is essential for liver hypertrophy and hyperplasia and eventual hepatocarcinogenesis in response to peroxisome proliferators. 

Sleight S. 1985. Effects of PCBs and related compounds on hepatocarcinogenesis in rats and mice. Environ Health Perspect 60 35-39. 

Cho, K.-J. Jang, J.-J. (1993) Effects of carbon tetrachloride, ethanol and acetaldehyde on di-ethylnitrosamine-induced hepatocarcinogenesis in rats. Cancer Lett., 70, 33-39... 

Matsumoto N, Kohri T, Okushio K, Hara Y. 1996. Inhibitory effects of tea catechins, black tea extract and Oolong tea extract on hepatocarcinogenesis in rat. Jpn J Cancer Res 87 1034-1038. 

Sultana, S., Ahmed, S., Jahangir, T. and Sharma, S. (2005) Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis modulation of cell proliferation, metabolism and altered hepatic foci development. Cancer Letters 221(1), 11-20. 

Curcumin was also effective against diethylnitrosamine (DEN)-induced murine hepatocarcinogenesis. Administration of 0.2% curcumin in the diet 4 days before DEN treatment and until death, i.e., at 42 weeks of age, suppressed the incidence (by about 62%) and multiplicity (by about 81%) of hepatocellular carcinomas. This inhibition of hepatocarcinogenesis was associated with the modulation of ras p21 and provided proliferating cell nuclear antigen (PCNA). 

Orner, G.A., J.D. Hendricks, D. Arbogast and D.E. Williams. Modulation of aflatoxin-B-1 hepatocarcinogenesis in trout by dehydroepiandrosterone initiation/post-initiation and latency effects. Carcinogenesis 19 161-167, 1998. 

Griffin AC, Jacobs MM. 1977. Effects of selenium on azo dye hepatocarcinogenesis. Cancer Letters 3 177-181. 

K Miyamoto, S Wakusawa, M Nomura, F Sanae, R Sakai, K Sudo, Y Ohtani, S Takeda, Y Fujii. Effect of gomisin A on hepatocarcinogenesis by 3 -methyM- dimethylamino-azobenzene in rats. Japan J Pharmacol 57 71-77, 1991. 

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