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Hepatitis C virus protease

Li XD, Sun L, Seth RB, Pineda G, Chen ZJ (2005) Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci USA 102 17717-17722... [Pg.23]

Steinkuhler C, Urbani A, Tomei L, Biasiol G, Sardana M, Bianchi E, Pessi A, De Francesco R (1996) Activity of purified hepatitis C virus protease NS3 on peptide substrates. J Virol 70 6694-6700... [Pg.109]

This procedure was later modified by the application of 4-(dimethylamino)pyridine as a catalyst in combination with Fmoc amino acid anhydrides in the course of the solid-phase syntheses of several depsipeptide substrates of human hepatitis C virus protease. Thus, Bianchi et al. 1111 synthesized the 13-membered depsipeptide Ac-Asp-Glu-Met-Glu-Glu-... [Pg.285]

Scheme 13 Fluorogenic Depsipeptide Substrates of Human Hepatitis C Virus Protease... Scheme 13 Fluorogenic Depsipeptide Substrates of Human Hepatitis C Virus Protease...
I. Hepatitis C Virus Protease Inhibitors Macrocyclic NS3 Serine Protease Inhibitors... [Pg.359]

New antiviral agents have been based on virus-specific targets, especially the viral enzymes that are involved in the viral life cycle, i.e. responsible for the production of infectious viral particles. Research has focused on virus-encoded proteases that fulfil this role. Thus, specific inhibitors of HIV, herpesvirus and hepatitis C virus proteases are now known. Examples of clinically approved HIV pro-... [Pg.184]

Hulskotte EG, Feng HP, XuanF, Gupta S, van Zutven MG, CYMara E, et al. Pharmacokinetic evaluation of the interaction between hepatitis C virus protease inhibitor boceprevir and 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors atorvastatin and pravastatin. Anti-microb Agents Chemother 2013 57(6) 2582-8. [Pg.434]

Hulskotte E, Gupta S, Xuan F, van Zutven M, (XMara E, Feng HP, et al. Pharmacokinetic interaction between the hepatitis C virus protease inhibitor boceprevir and cyclosporine and tacrolimus in healthy volunteers. Hepatology 2012 56(5) 1622-30. [Pg.434]

Linear and Macrocyclic Hepatitis C Virus Protease Inhibitors Inhibitor Design and Macrocyclization Strategies for HCV Protease and Related Targets... [Pg.253]

See other pages where Hepatitis C virus protease is mentioned: [Pg.108]    [Pg.345]    [Pg.140]    [Pg.286]    [Pg.506]    [Pg.512]    [Pg.34]    [Pg.361]    [Pg.363]    [Pg.365]    [Pg.491]    [Pg.495]    [Pg.337]    [Pg.476]    [Pg.444]    [Pg.409]   


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