Hepatic lesions tumors

Hepatic lesions (adenomas, focal nodular hyperplasia, hepatocellular carcinoma, etc) Rarely, benign and malignant hepatic adenomas have been associated with the use of hormonal contraceptives. Severe abdominal pain, shock, or death may be due to rupture and hemorrhage of a liver tumor. 

The measurement of tumor markers (where applicable) maybe used to monitor recurrence, with a sensitivity of 59% and a specificity of 84% [10]. In addition to its low sensitivity, tumor markers do not enable localization of recurrent lesions. CT has been the established imaging modality to demonstrate recurrent hepatic metastases or tumor progression after regional therapy. However, CT is unable to detect hepatic lesions in up to 7% of patients and underestimates the number of lobes involved in up to 33% of patients [10]. Selzner et al. [41] compared CT and... 

Recent development of a new PVA hydrogel bead has enabled accurate doxorubicin loadings to be achieved, with subsequent slow first order release. This novel drug-delivery system has been recently evaluated for intraarterial treatment of hepatic lesions [22], Doxorubicin-eluting beads (DC Bead for loading by the physician and PRECISION Bead preloaded with doxorubicin. Biocompatibles UK Ltd, Surrey, UK), are designed for intraarterial infusion and selective tumor targeting [14],... 

Jones et al. (1992) reported that in a series of more than 1400 patients referred for abdominal contrast-enhanced CT, 17% of patients had 15 mm or smaller liver lesions. In these series, 82 % of the patients had a known malignancy. Overall, 51% of lesions were classified as benign, 22% as malignant, and in 27% of patients the lesions could not be classified. In the subgroup of patients with known malignant tumors and single small hepatic lesions, only 5% of lesions were malignant. However, another 30% were deemed indeterminate. 

Lubiprostone (Amitiza) [Laxative] Uses Chronic idiopathic constipation in adults Action Selective Cl channel activator Dose Adults. 24 meg PO bid w/ food Contra Mechanical GI obst Caution [C, /-] Severe D, severe renal or mod-severe hepatic impair Disp Gel, caps meg SE N, HA, D, GI distention, abd pain EMS Monitor for signs of electrolyte disturbances and h5rpovolemia d/t D OD May cause severe D, hypovolemia, and abd pain/cramps give IV fluids Lutropin Alfa (Luveris) [Hormone] Uses Inf ility Action Recombinant LH Dose 75 Units SQ w/ 75—150 Units FSH, 2 s arate inj max 14 d Caution [X, /M] Contra Primary ovarian failure, uncontrolled thyroid/adrenal dysfxn, intracranial lesion, AUB, hormone-dqjendent GU tumor, ovarian cyst, PRG Disp Inj SE HA, N, ovarian h5rpCTstimulation synd, breast pain, ovarian cysts T risk of multiple births EMS None OD Unlikely to cause life-threatening Sxs... 

Liver cancer can be induced in rats by localized irradiation (UNSCEAR, 1977) or by a number of different chemicals and dosage schedules (Farber, 1984). Initiation-promotion protocols are also effective inducers of liver tumors. The predominant lesions are preneoplastic nodules, but as in the skin, carcinomas arise late in the process. Altered hepatic cell fod can be identified within a few weeks after the start of carcinogen treatment by specific changes in enzyme activity, inability... 

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