Hepatic glucose metabolizing mechanism

Inhibition of Hepatic Glucose Metabolizing Enzymes Mechanism... 

Although hematological, biochemical, hepatic, and renal parameters are not specific for DNOC exposure, these parameters may be measured to determine disease states caused by DNOC. One animal study demonstrated changes in these parameters following oral exposure to DNOC for intermediate-duration (Den Tonkelaar et al. 1983). Based on DNOC s mechanism (uncoupling of exudative phosphorylation), urinary ketone levels and urine and blood glucose levels may be monitored for effects on carbohydrate metabolism. 

In summary, our results define an important role for PPARa in the maintenance of cellular lipid and glucose homeostasis in vivo via the transcriptional control of target genes encoding mitochondrial and extra-mitochondrial fatty acid oxidation enzymes. We also demonstrate that gender-related mechanisms are involved in hepatic and cardiac lipid metabolism. Lastly, we propose that the PPARa -/- mouse may prove useful as a model of human diseases due to inborn and acquired alterations in cellular lipid metabolism. 

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