Hepatic fructose-1,6-diphosphatase deficiency

Glycerol is used as a therapeutic agent to reduce elevated intracranial and intraocular pressure and, until recently, was considered safe for oral and intravenous use. However, children with hepatic fructose-1,6-diphosphatase deficiency may develop lactic acidosis and hypoglycaemia after the use of glycerol. In adults, 20% glycerol in isotonic saline has caused haemolysis, haemoglobinuria and acute renal failure (42). 

Baker L, Winegrad AI (1970) Fasting hypoglycaemia and metabolic acidosis associated with deficiency of hepatic fructose-1,6-diphosphatase activity. Lancet ii 13 16... 

---