Hendrie, Hugh

Hendry JE and Hughes RR (1972) Generating Separation Process Flowsheets, Chem Eng Prog, 68 71. 

Hendry, J.E., Hughes, R.R. Generating Separation Process Flowsheets, Chemical Engineering Progress, June 1972, p. 71... 

Cl-988 has been found to reduce the behavioral stress in marmosets exposed to a human threat [Hughes et al. 1990]. L-365,260 can antagonize the behavioral effects of exposition to the odor of a cat in rats and suppress the behavioral reaction of mice to the calls of an owl, an effect also found with LY 288513 (Hendrie and Dourish 1994]. Thus, evidence suggests an anxiolytic activity of CCK-B antagonists. The activity seems more evident in etho-logically based models of anxiety than in conflict-based tests and does not follow a linear dose-dependent relationship but rather a bell-curve one. Also, most studies point to a selectivity of CCK-B antagonists, but not CCK-A antagonists, for anxiolytic effects. 

Hendry JE, Hughes RR. Generating separation process flowsheets. Chem Eng Prog 1972 68 71. 

The representation used for this problem is always some variation of the split list, originally described by Hendry and Hughes (1972). Figure 4 illustrates. 

Hendry, J.E. and Hughes, R.R., List Processing Representation of Separation Operations, University of Wisconsin, August 20, 1975. 

A general review on distillation synthesis can be found in Westerberg (1985) and Floquet et ai. (1988). The synthesis of simple separation sequences based on heuristics is fairly well developed. Enumeration search methods (dynamic programming, branch-and-bound) have been proposed by Hendry and Hughes (1972) and Gomez-Munoz and Seader (1985), while evolutionary search procedures have been described by Stephanopoulos and Westerberg (1976), Seader and Westerberg (1977) and Nath and Motard (1981). 

An industrial separation problem may be defined in terms of a process feed and specifications for the desired products. An example adapted from Hendry and Hughes/ based on a separation process for a butadiene processing plant, is given in Fig. 1.16. 

Example 14.2. Consider the separation problem studied by Hendry and Hughes as shown in Fig. 1.16. Determine the feasibility of two-product, ordinary distillation (method I), select an alternative separation technique (method II), if necessary, and forbid impractical splits. Determine the feasible separation subproblems and the number of possible separation sequences that incorporate only these subproblems. 

The decimal numbers in Fig. 14.6 are annual costs for the separations in thousands of dollars per year as derived from data given by Hendry. The sequence costs are listed in Table 14.4. The lowest-cost sequence is illustrated in Fig. 1.20 the highest-cost sequence is 31% greater in cost than the lowest. If only the (A/C...) and i...ElF)u splits are prohibited as by Hendry and Hughes, the consequence is 64 unique separation subproblems and 227 sequences. However, every one of the additional 215 sequences is more than 350% greater in cost than the lowest-cost sequence. 

Lange K (1978) Nephropathy induced by D-penicillamine. Contrib Nephrol 10 63-74 Leifer W, Steiner K (1951) Studies in sensitization to halogenated hydroxy-quinolines and related compounds. J Invest Dermatol 17 233-240 Levi AJ, Fisher AM, Hughs L, Hendry WF (1979) Male infertihty to sulphasalazine. Lancet 2 276-277... 

Rathore et al. suggested a technique using the list processing approach of Hendry and Hughes along... 

The approach used here k to treat separators as list-processing operations using dynamic programming and ranked Ikts to develop the optimum sequence. The procedure, as originally described by Hoidiy and Hughes and later summarized by Hendry et al., can be described as follows ... 

Seader and Westerbeig" used a set of six heuristics along with several evolutionaiy mies to construct an optimal sequence for the separation problems presented by Hendry and Hughes and Thompson and King. They noted that their technique resulted in a much more rapid and concise treatment of the problem than earlier methods. 

Knowledge of the biosynthesis of bark beetle pheromones has been largely conjectural, based on simple metabolic pathways from host terpenes. However, the biosynthetic routes of the pheromone components of 7. paracon-fusus are now known (Fig. 12.3). Both sexes produced m-verbenol when exposed to (-)ff-pinene (Renwick et al., 1976), and tran -verbenol from (+)a-pinene. When exposed to the vapour of myrcene, ipsdienol and ipsenol appeared in the hindguts of male beetles, but not in females (Hughes, 1974 Hughes and Renwick, 1977 Byers et al., 1979), whereas no pheromone was detected in the guts of beetles not exposed to myrcene. Deuterium-labelling techniques have now confirmed that myrcene is converted in male I. para-confusus to ipsdienol and ipsenol (Hendry et al., 1980). Thus, all three known pheromone components are obtained by simple oxidation of host plant chemicals. 

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