Hemostatic preparations

One of the most characteristic reactions of the aminochromes is the ready formation of mono-derivatives with typical ketone reagents, e.g. semicarbazide, phenylhydrazine, etc. A relatively large number of derivatives of this nature have been prepared because of then-reported hemostatic activity (cf. refs. 2 and 3). Compounds of this type that had been described in the literature prior to December 1959 are listed in a previous review (Heacock3). Some further examples of this class of compounds have been described recently. They are N-ethylnoradrenochrome semicarbazone (84) (orange-red needles, m.p.180 215°)65 7-iodoadrenochrome methyl ether semicarbazone... 

Hyaluronic acid succinylate, (II), was prepared by Rivarossa [2] by reacting succinic anhydride with sodium hyaluronate and the material used in either venous and arterial vascular anastomoses. This included creating a physical hemostatic barrier to prevent scar tissue formation or to prevent post surgical adherence of the vessels to the surrounding tissues. Laredo [3] prepared... 

The hemostatic efficacy of rAHF-PFM and rAHF were compared in hemophilic, exon-16 knockout mice using the tail transection model. Bleeding rate and cumulative blood loss after treatment, for both preparations, were similar (Fig. 3.7). 

Method of preparation administration Carbonize equal parts of the above medicinals in a sealed container and then grind into a fine powder. Take 9-15g of this powder made into pills mixed with ink made from a Chinese inkstick ground in either lotus root juice or white radish juice. However, this powder can also be added to other formulas as a heat-clearing hemostatic ingredient. It can also be prepared as a decoction on its own. 

Heparin, one of the most widely used blood anticoagulants, is an expensive product. Attempts have been made to prepare a number of synthetic anticoagulants, but none are as nontoxic as heparin. It has been reported that cellulose and starch sulfuric acid esters are toxic, whereas chitin disulfuric acid is less toxic. It has also been reported that the protein moiety of chitin is responsible for the inflammatory response when material containing chitin is injected into tissues of higher animals, whereas pure chitin does not give a detectable response. Dutkiewicz et al. [218] have shown that chitosan exhibits not only a hemostatic effect, but also has anticoagulant properties. Some variation... 

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