Hemoglobin synthesis induction

Resar LMS, Segal JB, Fitzpatric LK, et al. Induction of fetal hemoglobin synthesis in children with sickle cell anemia on low-dose oral sodium phenylbutyrate therapy. J Pediatr Hematol Oncol 2002 24 737— 741. 

Erythroid cells afford a system for the study of cell differentiation and of control mechanisms in protein synthesis. In this discussion we are concerned with the differentiation of erythroid cells, the induction of hemoglobin synthesis, the regulation of the synthesis of heme and of globin, and the role of heme in the synthesis and assembly of hemoglobin. 

ERYTHROID CELL DIFFERENTIATION AND THE INDUCTION OF HEMOGLOBIN SYNTHESIS... 

The difiFerentiation of erythroid cells, the induction of hemoglobin synthesis, and the switch from embryonic and fetal to adult hemoglobin synthesis, may be explicable in terms of control at the level of transcription of genes. Processes such as the coordination of synthesis of heme and globin and of assembly of a and j8 chains, which are operative during stages of erythroid cell development in which no RNA is synthesized, are more likely to be explicable in terms of translation. 

Moss, B., and Ingram, V. M. (1965). The repression and induction by thyroxin of hemoglobin synthesis during amphibian metamorphosis. Proc. Natl. Acad. Sci. U.S. 54, 967-974. 

---