Hemoglobin equation

We can determine quantitatively the physiological significance of the sigmoid nature of the hemoglobin oxygen-binding curve, or, in other words, the biological importance of cooperativity. The equation... 

That is, the situations for myoglobin and hemoglobin differ therefore, P50 and K cannot be equated for Hb because of its multiple, interacting, Oa-binding sites. The relationship between and P50 for hemoglobin, by use of Equation (A15.12), becomes... 

In some of his earliest work, published in 1910, A. V. Hill examined how the binding of oxygen to hemoglobin varied with the oxygen partial pressure. He found that the relationship between the two could be fitted by the following equation ... 

Oxy- and deoxy-hemoglobins are mainly of interest because they are related to the regional cerebral blood flow (rCBF). The focal change in rCBF determines the activation state. The term activation usually refers to the focal increase in rCBF whereas a decrease is called deactivation [78]. With the dual wavelength approach, one can derive two simultaneous equations to be solved for each of the two chromophore concentration changes. To this end, Equation (4) is split into two parts, separating the contributions from HbO and Hb. Equation (4) is then, rewritten as... 

Percent hemoglobin deficiency, D, may be calculated from the following equation ... 

Isotherm Subtraction. A second method (7) of determining the net proton coefficient from adsorption data is an adaptation of the thermodynamics of linked functions as applied to the binding of gases to hemoglobin (19). The net proton coefficient determined by this method is designated, Xp- The computational procedure makes a clear distinction between the influence of adsorption density and pH on the magnitude of the net proton coefficient. The fundamental equation used in the calculation of Xp is... 

The thermodynamic association (or dissociation) constants used in the Adair equation for a ligand binding at sites in a multisite protein. The term Adair constants originally referred only to the four constants for the reversible binding of dioxygen to hemoglobin. See Adair Equation... 

Linked-function mechanisms for cooperative binding interaction of metabolites and/or drugs, based on the presence of two or more different conformational states of the protein or receptor. See Adair Equation Cooperative Ligand Binding Hemoglobin Hill Equation Plot Koshland-Nemethy-Filmer Model Monod-Wyman-Changeux Model Negative Cooperativity Positive Cooperativity... 

This expression is called a linked function and indicates how the binding of ligands at nearby sites can influence each other. See also Basic Regulatory Kinetics Cooper-ativity Allosterism Feedback Effectors Bohr Effect Hemoglobin Le Chatelier s Principle Adair Equation... 

ADAIR EQUATION COOPERATIVE LIGAND BINDING HILL EQUATION PLOT KOSHLAND-NEMETHY-EILMER MODEL MONOD-WYMAN-CHANCEUX MODEL NEGATIVE COOPERATIVITY POSITIVE COOPERATIVITY HEMOGLOBIN ALLOTOPIC EFFECT Allowed electronic transitions,... 

LINKED EUNCTIONS HEMOGLOBIN ADAIR EQUATION BOLTZMANN DISTRIBUTION LAW CRYOENZYMOLOGY BOLUS... 

HEMOGLOBINS POLYMERIZATION RESONANCE RAMAN SPECTROSCOPY HEMOGLOBIN-S POLYMERIZATION HENDERSON-HASSELBALCH EQUATION HENDERSON PLOT Henri-Brown treatment,... 

BASIC REGULATORY KINETICS BOHR EFFECT COOPERATIVITY FEEDBACK EFFECTORS LE CHATELIER S PRINCIPLE HEMOGLOBIN ADAIR EQUATION LINOLEATE ISOMERASE Linoleoyl ester,... 

K-Assay LPO-CC Oxidation by lipid hydroperoxides of a derivative of the leuco form of Methylene Blue (90) to the colored form (91), catalyzed by hemoglobin, according to equation 29 measurement is at 675 nm . e... 

The hemoglobin-catalyzed oxidation of o-phenylenediamine to 2,3-diaminophenazine (100), in phosphate-citric acid buffer at pH 5.0, shown in equation 30, is the basis for a kinetic method for determination of H2O2, in a FIA system, measuring at 425 mn by the stopped-flow method. The LOD is 9.2 nM, with RSD 2.08% at 0.5 p,M and linearity in the 50 to 3500 nM range . This colorimetric method was proposed for development as a standard procedure in the Republic of China for determination of H2O2 in foodstuffs . ... 

This is the equation for the hyperbolic curve shown in Fig. Hemoglobin with its four subunits has more complex behaviour it approximately follows the equation... 

---