Hematuria 424 Subject

A case report of acute arsine poisoning in which a 27-y-old man was exposed to arsine during chemical manufacturing was reported by Pinto (1976). The subject was exposed to arsine as a result of arsine production via a reaction between a galvanized bucket and an arsenic-containing sulfuric acid solution. The exposure (duration not specified) produced toxic effects characterized by abdominal cramping, thoracic discomfort, and hematuria. Over the next week, the patient s hematocrit declined from 42.5 to 27.1 and hemoglobin dropped from 14.1 to 9.5 g/dL even with medical intervention (blood transfusions and mannitol diuresis). Nine hours after exposure, blood arsenic was 159 g/dL and urinary arsenic was 1862 ug/L. 

Kleinfeld (1980) reported a case of arsine poisoning in a 31-y-old man. The exposure to arsine occurred from a leaking canister thought to be empty. The exposure duration was estimated to be 1-2 min, but no actual or estimated arsine concentrations were available. The victim presented with hematuria. On hospital admission, no intact erythrocytes were present in the urine, hematocrit was 43%, and hemoglobin was 9.8 g/ dL. The hematocrit dropped to as low as 18%, the correction of which required one unit of packed cells. Based upon the exposure history and the subject s note of a "garlicky" odor, the diagnosis was arsine-induced hemolytic anemia. Urinary arsenic was 7.2 mg/L on admission and 0.1 mg/L 4 d later. The patient was subsequently discharged. 

Proapted by a report of hematuria In a subject receiving EA 3834, research was begun on the effects of these drugs on ureteral and bladder motility (25). Microscopic hematuria was shown to occur within several minutes after Intravenous administration of EA 3834 and usually cleared within 1 h. The dogs had ureteral or bladder catheters In place and often had a few red blood cells In the urine before administration of the agent. However, the red cells became much more numerous after administration. No additional Information Is available ... 

In one subject, fever and spastic movements of Che head were noted he was treated vigorously with antidotes. At 3 h, he became unresponsive, showed decerebrate rigidity, had a high heart rate, and had urinary retention he was treated vigorously with antidotes. Five years later (1968), he was hospitalized for microscopic hematuria and was shown by renal biopsy to have focal glomerullcls. 

Klapper et al. (162) reported the results of followup studies on two men who had been given 3-qulnuclldlnyl benzllate and one who had been given L-2-alpha-troplnylbenzllate earlier. The first two had histories of Intermittent hematuria before their service as volunteer subjects at the times of the followup examinations, they had fewer chan 10 red blood cells per hlgh-power field In their urine. One of them reported chat he had had a flashback of his experiences under the Influence... 

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