Hematuria intravenous

Intravenous pyelogram (IVP) will show retention of radio-contrast in the bladder if the patient has bladder outlet obstruction due to an enlarged prostate only indicated in patients with recurrent hematuria, recurrent urinary tract infection, renal insufficiency, and urolithiasis... 

Intravenous fluids are very important to maintain normovolemia and urine output. If hematuria is present, consider alkalinization of the urine. A goat anti-ricin polyclonal and a mouse anti-ricin A-chain monoclonal antibody have been tested and shown to neutralize ricin in castor bean extract, but they are not clinically available (Lemley and Wright, 1991 Wannemacher et al, 1991). 

Proapted by a report of hematuria In a subject receiving EA 3834, research was begun on the effects of these drugs on ureteral and bladder motility (25). Microscopic hematuria was shown to occur within several minutes after Intravenous administration of EA 3834 and usually cleared within 1 h. The dogs had ureteral or bladder catheters In place and often had a few red blood cells In the urine before administration of the agent. However, the red cells became much more numerous after administration. No additional Information Is available ... 

Intravenous dimethylsulfoxide poses the greatest problems and causes transient systemic hemolysis with hemoglobinuria, but without gross hematuria. The hemolysis is dose-dependent and appears within several minutes after infusions of dimethylsulfoxide 20-40% (11). There was no evidence of kidney damage because of handling higher amounts of hemoglobin after hemolysis. 

A 49-year-old man with resistant rheumatoid arthritis took leflunomide 100 mg/day for 3 days. His international normalized ratio (INR) had been stable for 1 year while he was taking warfarin, and 2 days before starting treatment with leflunomide it was 3.4. After he took the second dose of leflunomide, he developed gross hematuria. His INR had risen to 11, and warfarin was withdrawn. The hematuria resolved spontaneously several hours later, but his INR remained raised for the next 2 days, even though he had stopped taking warfarin. He was given intravenous vitamin K 1 mg on the third day, and 12 hours later the INR fell to 1.9. 

Patients with IgA nephropathy have abnormal production of IgA and several different immunoglobulins. High-dose immunoglobulins, initially administered intravenously followed by the intramuscular route, for over 9 months arrested the decline of renal function and reduced hematuria and proteinuria in aU of the 11 patients evaluated. The efficacy of this regimen must be confirmed in a larger number of patients before it is used as primary therapy. 

Ample fluid intake is recommended for routine clinical use, and vigorous intravenous hydration is required during high-dose treatment. Brisk hematuria in a patient receiving daily oral therapy should lead to immediate drug discontinuation. Refractory bladder hemorrhage may require cystectomy for control of bleeding. 

Pharmacokinetics Doxorubicin and daunorubicin must be given intravenously. They are metabolized in the liver, and the products are excreted in the bile and the urine (the red color is not hematuria). 

Urinary tract Renal insujficiency and hematuria are rare after the administration of intravenous immunoglobulin, and most often occur in patients with pre-existing renal impairment. Products that contain sucrose carry a higher risk of renal adverse events [1 53 54 ]. 

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