Heart malformation

Developmental effects of trichloroethylene exposure have been demonstrated with the FETAX (Frog Embryo Teratogenesis Assay Xenopus) bioassay, an in vitro method using whole frog embryos (Fort et al. 1991, 1993 Rayburn et al. 1991). Observed defects included gut miscoding, skeletal kinking, and heart malformations heart malformations have also been observed in rat developmental assays (Dawson et al. 1993). [Pg.139]

Isotretinoin Central nervous system, ear, and heart malformations... [Pg.726]

Anddewicz DS, Bums CG, Camey S A, Peterson RE, Heideman W (2005) Heart malformation is an early response to TCDD in embryonic zebrafish. Toxicol Sci 84 368-377... [Pg.412]

Wolkowski-Tyl R et ah Evaluation of heart malformations in B6C3F1 mouse fetuses induced by in utero exposure to methyl chloride. Teratology 21 . 91-206, 1983... [Pg.463]

E 16, 32, 64, 71, 78 mg/L Gut miscoilin0 from 32 mg/L. Axis malformation and edema from 64 mg/L Eye malformation (failure of the choroid, irregular shape with abnormal pigmentation) from 32 to 78 mg/L. Heart malformation Lfnderdeveloped (1 larva/concentration at 71, 78 mg/L) External malformation Domed head with hydrocephaly (4 fetuses from 2 litters at 1,000 mkd, two with microglossia). Domed head with hydrocephaly in the preliminary study (4 fetuses from 2 litters at 1,000 mkd, one with microglossia). Visceral malformation 1 Microcardia... [Pg.415]

Britz-Cunningham SH, Shah MM, Zuppan CW, Fletcher WH Mutations of the connexin 43 gap junction gene in patients with heart malformations and defects of laterality. N Engl J Med 1995 332 1323-1329. [Pg.122]

Cardiovascular Heart malformations (AV canals secundum ASD, patent ductus arteriosus VSD) ... [Pg.583]

The family-linked British Columbia files have in addition yielded sib risk data for such conditions as strabismus, clefts of the palate and lip, clubfoot, heart malformations, spina bifida, and epilepsy of children. 27) It would thus be technically feasible to compare systematically for a wide range of diseases the actual risks among siblings of affected people with those expected for multifactorial quasicontinuous inheritance. [Pg.67]

P. Chen, L.J. Xie, G.Y. Huang, X.Q. Zhao, C. Chang, Mutations of connexin43 in fetuses with congenital heart malformations. Chin Med J (Engl) 118 (2005) 971-976. [Pg.104]

OUey, P. M., Coceani, F. and Bodach, E. (1976) E-type prostaglandins a new emergency therapy for certain cyanotic congenital heart malformations. Circulation, 53, 728. [Pg.328]

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