Headache somatropin

Headache is a common adverse effect of somatropin. It often occurs early in treatment and usually responds to temporary dosage reduction followed by gradual re-esca-lation (1,24). It can be an early indicator of the rare complication pseudotumor cerebri (idiopathic intracranial hypertension), particularly in high-risk groups, such... 

A non-obese 6-year-old girl with Ullrich-Turner syndrome developed headache, vomiting, and blurred vision, with papilledema and increased cerebrospinal fluid pressure 5 months after starting somatropin 0.9 IU/kg/week (30). The cerebrospinal fluid pressure normalized after somatropin was withdrawn, and increased again when therapy was restarted. Her visual acuity was reduced to less than 30% in the right eye. 

Side effects of the long-acting somatropin injectable suspension have included injection-site nodules that persist for 5-7 days (96%), edema, arthralgias, transient fatigue (24%), mild-moderate nausea (24%), and headache (36%). 

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