Headache diethylcarbamazine

Side effects associated with diethylcarbamazine include headache, malaise, weakness, and loss of appetite. More severe reactions (fever, acute inflammatory response) may also occur following diethylcarbamazine use, but these reactions may be caused by the release of antigenic substances from the dying roundworms rather than from the drug itself. 

Diethylcarbamazine kills both microfilariae and adult worms. Fever, headache, anorexia, malaise, urticaria, vomiting and asthmatic attacks following the first dose are due to products of destruction of the parasite, and reactions are minimised by slow increase in dosage over the first 3 days. 

Adverse reactions to treatment with diethylcarbamazine vary with the infecting filarial species and are most severe in onchocerciasis. Minor reactions include malaise, nausea, and headache, but diethylcarbamazine also depresses the central nervous system in some individuals, resulting in dizziness and somnolence reversible coma has been reported in patients in poor physical condition. Nicotine-like properties can produce autonomic effects. A degree of eosinophilia during treatment is usual. 

Cardiac arrhythmias precordial pain muscle weakness cellulitis at site of injection diarrhea vomiting peripheral neuropathy heart failure headache dyspnea Diethylcarbamazine Citrate USP... 

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