HDAC6 A Master Regulator of Cell Response to Cytotoxic Insults

4 HDAC6 A Master Regulator of Cell Response to Cytotoxic Insults 

The results described above indicate that HDAC6 inhibition would likely be detrimental and result in exacerbation of protein misfolding and cellular stress in 

Similarly, Kozikowski et al. used the hydroxamate metal-binding group and a flexible C6 alkyl linker and developed a [2+3] cycloaddition approach to optimize the surface recognition element [241]. This work culminated in the isoxazole 62, for which an IC50 value of 2 pM against HDAC6 and significant selectivity over several 

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