Hard tissues Raman spectroscopy

Connective tissues have often been reported in Raman and FT-IR images adjacent to epitheUum or carcinomas. Articular cartilage [15], ECM damage [16], and sarcoma, which is a neoplastic process originating within connective tissue [17], were studied by Raman spectroscopy. Applications of vibrational spectroscopic imaging to bone, which belongs to supportive connective tissue and is considered as hard tissue, are described in Chapter 4 of this book. 

Vibrational spectroscopy provides information on the functional groups present in the mineral and organic matrix components of hard tissues, as well as their molecular neighborhood [2,3]. The mineralized tissue components and properties that can be easily determined through both Fourier transform infrared (FT-IR) or Raman spectroscopic analysis and their biological significance are as follows ... 

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