Quetiapine Haloperidol

Haloperidol, quetiapine Monitor clinically may require a dose increase or use of an alternate psychotropic drug. 

Test Psychosis patients Clozapine Haloperidol Quetiapine BPAD patients Lithium Valproate Carbar... 

Haloperidol, phenothiazines, thioxanthenes, clozapine, olanzapine, quetiapine, and risperidone 0 Parenteral agents may have a higher incidence... 

Side Effect Clozapine Risperidone Olanzapine Quetiapine Ziprasidone Aripiprazole Haloperidol... 

Conventional antipsychotic drugs such as chlorpromazine and haloperidol have long been used in the treatment of acute mania. More recently, atypical antipsychotic drugs including aripiprazole, olanzapine, quetiapine, risperidone, and ziprasi-done have been approved for the treatment of bipolar mania or mixed mood episodes as monotherapy or in combination with mood-stabilizing drugs.25 Aripiprazole and olanzapine are also approved for maintenance therapy. The combination of olanzapine and fluoxetine is approved for treatment of bipolar depression. Quetiapine is approved for treatment of... 

Current antipsychotics used to treat patients are divided into two classes the first generation antipsychotics (FGA) or typicals (e.g., chlorproma-zine, haloperidol, thioridazine, and loxapine) and the second generation antipsychotics (SGA) or atypicals (i.e., clozapine, olanzapine, quetiapine, risperidone, aripiprazole, ziprasidone, and asenapine). 

Agitation (acute, severe) Lorazepam Ziprasidone Risperidone Trazodone Olanzapine Quetiapine Haloperidol... 

Brief Severe Agitation. Acute management of severe agitation with physical aggression requires more definitive treatment. The first choice is haloperidol given in low doses (0.25-1 mg) as needed. Lorazepam can also be helpful if used briefly. Risperidone, olanzapine, quetiapine, or trazodone can also be used but are not available in injectable forms. 

Antidepressants tricyclics, fluoxetine, paroxetine, sertraline, mirtazepine, venlafaxine, mianserin Antipsychotics phenothiazines, haloperidol, clozapine, olanzapine, quetiapine... 

Tardive dyskinesia refers to uncontrollable facial movements. It is more likely to occur in the elderly. Tardive dyskinesia is commonly associated with the use of antipsychotic drugs, such as haloperidol. The atypical antipsychotics, such as clozapine, olanzapine, risperidone and quetiapine are less likely to cause tardive dyskinesia. 

In the Expert Consensus survey, the respondents endorsed risperidone, olanzapine, and quetiapine, in that order, followed by high-potency traditional antipsychotics, for managing self-injury. A placebo-controlled study comparing risperidone with a classical antipsychotic, such as haloperidol, could provide valuable data for this field. 

Arvanitis LA, Miller BG Multiple fixed doses of Seroquel (quetiapine) in patients with acute exacerbation of schizophrenia a comparison with haloperidol and placebo. The Seroquel Trial 13 Study Group. Biol Psychiatry 42 233-246, 1997... 

D2 receptor, albeit with different specificity. Older examples of dopamine antagonists are chlorpromazine, haloperidol and many derivatives of these prototype compounds. Newer antipsychotic drugs such as risperidone, olanzapine and quetiapine have retained this mechanism of action, although no longer exclusively. 

Arvanitis and Miller (129) reported a multiple fixed-dose, placebo-controlled, double-blind study of quetiapine in comparison with haloperidol and placebo in acutely exacerbated patients with chronic schizophrenia. Quetiapine was administered in five doses 75, 150, 300, 600, and 750 mg/day haloperidol was given at 12 mg/day. The study design had slightly more than 50 patients in each group. The 75-mg dose of quetiapine was clearly less efficacious than the higher doses. Doses of 150 to 750 mg/day were superior to placebo and comparable with haloperidol in reducing positive symptoms and 300 mg/day was superior to placebo and comparable with haloperidol for negative symptoms. 

Using meta-analytic techniques based on the means and the standard errors presented graphically in the poster, we estimated pooled data of the four effective dosages of quetiapine both for the BPRS and the CGI severity of illness change scores from baseline to endpoint. Quetiapine produced an improvement of 0.43 effect-size units in comparison with placebo, a difference that was highly statistically significant and about the same improvement as haloperidol. Thus, based on the BPRS or PANSS, quetiapine was similar to neuroleptics in efficacy (i.e., differences were nonsignificant). Based on our meta-analysis, quetiapine is clearly superior to... 

TABLE 5-15. Quetiapine versus placebo or haloperidol for schizophrenia acute treatment... 

Lower potency neuroleptics, such as thioridazine and chlorpromazine, have a decreased incidence of EPS when compared with higher potency agents, such as haloperidol or fluphenazine. Novel agents, such as clozapine and quetiapine, are virtually devoid of EPS effects when given at their recommended dosing range. 

Hyperlipidemia associated with antipsychotic drugs has been reviewed (SEDA-29, 64). Haloperidol and the atypical antipsychotic drugs ziprasidone, risperidone, and aripiprazole would be associated with lower risks of hyperlipidemia, whereas chlorpromazine, thioridazine, and the atypical drugs quetiapine, olanzapine, and clozapine would be associated with higher risks. However, severe clozapine-induced hypercholesterolemia and hypertriglyceridemia has been reported in a patient taking clozapine (55). 

The effects of haloperidol and quetiapine on serum prolactin concentrations have been compared in 35 patients with schizophrenia during a drug-free period for at least 2 weeks in a randomized study (475). There was no significant difference in prolactin concentration between the groups at the start of the study control prolactin concentrations were significantly lower with quetiapine than with haloperidol. Two patients taking haloperidol had galactorrhea related to hyperprolactinemia. 

Atmaca M, Kuloglu M, Tezcan E, Canatan H, Gecici O. Quetiapine is not associated with increase in prolactin secretion in contrast to haloperidol. Arch Med Res 2002 33(6) 562-5. 

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