Haloperidol conduct disorders

Haloperidol Butyrophenone 0.25-15 High 2 Autistic disorder Conduct disorder Schizophrenia Tic disorders Anderson et ah, 1984 Campbell et ah, 1984 Spencer and Campbell, 1984 Shapiro et ah, 1989... 

Campbell, M., Small, A.M., Green, W.H., Jennings, S.J., Perry, R., Bennett, W.G., and Anderson, L. (1984) Behavioral efficacy of haloperidol and lithium carbonate. A comparison in hospitalized aggressive children with conduct disorder. Arch Gen Psychiatry 41 650-656. 

Both typical (e.g., haloperidol) and atypical (e.g., clozapine) antipsychotics are used in children and adolescents, primarily to treat schizophrenia, psychotic mood disorder, and pervasive developmental disorders. These agents are also used on occasion to treat a range of other conditions including conduct disorder, impulsive and aggressive disorders, Tourette s disorder, and ADHD. 

No formal, prospective, long-term efficacy or safety studies of either typical or atypical antipsychotics in children and adolescents with schizophrenia have been conducted (166, 167). However, reports of the long-term treatment of children and adolescents with conduct disorder (181, 182), autism (183), and Tourette s disorder (184) with either haloperidol or thioridazine suggest that the tolerability of these medications in children and adolescents is comparable with that in adults. 

Methyldopa [Aldomet) [Antihypertensive/Centrally Acting Antiadrenergic] Uses HTN Action Centrally acting antihypertensive Dose Adults. 250-500 mg PO bid-dd (max 2-3 g/d) or 250 mg-1 g IV q6-8h Peds. 10 mg/kg/24 h PO in 2-3 + doses (max 40 mg/kg/24 h - q6-l2h) or 5-10 mg/kg/dose IV q6-8h to total dose of 20—40 mg/kg/24 h i in renal insuff/elderly Caution [B (PO), C (IV), +] Contra Liver Dz MAOIs Disp Tabs, inj SE Discolors urine inidal transient sedadon/drowsiness frequent, edema, hemolydc anemia, hepadc disorders Interactions T Effects W/ anesthetics, diuredcs, levodopa, Li, methotrimeprazine, thioxanthenes, vasodilators, verapamil T effects OF haloperidol, Li, tolbutamide 1 effects W7amphetamines, Fe, phenothiazine, TCAs 1 effects OF ephedrine EMS Use diuredcs, verapamil, and sympathomimedcs w/ caudon may T risk hypotension, arrhythmias and pressors effects OD May cause profound hypotension, drowsiness, and impaired myocardial conduction activated charcoal may be effective... 

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