H- Bredts

Silvango, F., Xia, H., Bredt, D.S. (1996). Neural nitric oxide synthase an alternatively spliced isoform expressed in differentiated skeletal muscle. J. Biol. Chem. 271 11204-8. 

Zhdanov, R.I. Bioactive Spin Labels. Soringer-Verlag Berlin, Germany, 1992. Snyder, S.H. Bredt, D.S. ScL Amer. 1W2, 5, 68. 

Chromium aminocarbenes [39] are readily available from the reaction of K2Cr(CO)5 with iminium chlorides [40] or amides and trimethylsilyl chloride [41]. Those from formamides (H on carbene carbon) readily underwent photoreaction with a variety of imines to produce /J-lactams, while those having R-groups (e.g.,Me) on the carbene carbon produced little or no /J-lactam products [13]. The dibenzylaminocarbene complex underwent reaction with high diastereoselectivity (Table 4). As previously observed, cyclic, optically active imines produced /J-lactams with high enantioselectivity, while acyclic, optically active imines induced little asymmetry. An intramolecular version produced an unusual anti-Bredt lactam rather than the expected /J-lactam (Eq. 8) [44]. 

Dawson, V.L., Dawson, T.M., London, E.D., Bredt, D.S. and Snyder, S.H. (1991). Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl Acad. Sci. USA 88, 6368-6371. 

Selective oxidations are possible for certain bicyclic hydrocarbons.285 Here, the bridgehead position is the preferred site of initial attack because of the order of reactivity of C—H bonds, which is 3° > 2° > 1°. The tertiary alcohols that are the initial oxidation products are not easily further oxidized. The geometry of the bicyclic rings (Bredt s rule) prevents both dehydration of the tertiary bridgehead alcohols and further oxidation to ketones. Therefore, oxidation that begins at a bridgehead position... 

Bredt, D. S. Snyder, S. H. (1992). Nitric oxide, a novel neuronal messenger. Neuron 8, 3 11. 

D.S. Bredt, P.M. Hwang, C.E. Glatt, C. Lowenstein, R.R. Reed, and S.H. Snyder, Cloned and expressed nitric-oxide synthase structurally resembles cytochrome-P-450 reductase. Nature 351, 714-718 (1991). 

D.S. Bredt and S.H. Snyder, Nitric-oxide mediates glutamate-linked enhancement of cgmp levels in the cerebellum. Proc. Natl. Acad. Sci. U.S.A. 86, 9030-9033 (1989). 

Isolated in an argon matrix at 10 K, singlet 107 displays an absorbance at 620 nm due to a lone pair to p orbital transition irradiation at 620 nm converts 107 to its 1,3-CH insertion product, dehydroadamantane, 108.120 This product is much less strained than the alternative, antt -Bredt, 1,2-H shift alkene, 109. 

McMillan, K., Bredt, D. S., Hirsch, D. J., Snyder, S. H., Clark, J. E., Masters, B. S., Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide, Proc. Natl. Acad. Sci. USA 89 (1992), p.11141-11145... 

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