H blood group substance

Fig. 26. H blood group substance and HCl concentration in gastric juice...

G43. Class, G. B. J., Ishimori, A., and Buckwalter, J. A., ABO(H) blood group substances of the gastric juice in peptic ulcer, cancer of the stomach, and atrophic lesions of the gastric mucosa. Gastroenterology 42, 443-454 (1962). 

In studies performed in association with J. A. Buckwalter s group from Iowa City, we studied the distribution of ABO(H) blood group substances in the electrophoretic partition of gastric juice (G3a, G6). Several acid and anacid pools of gastric juice were subjected to continuous electrophoresis on paper curtain in borate buffer of pH 9.0, 0.06. The... 

Chemistry of Tissues. 3. Blood Group Substances from Human Gastric Contents, H. G. Bray, H. Henry, and M. Stacey, Biochem. J., 40 (1946) 130-134. 

The ABO substances have been isolated and their structures determined simphfied versions, showing only their nonreducing ends, are presented in Figure 52—6. It is important to first appreciate the structure of the H substance, since it is the precursor of both the A and B substances and is the blood group substance found in persons of type O. H substance itself is formed by the action of a fiicosyltransferase, which catalyzes the addition of the terminal fiicose in al —> 2 linkage onto the terminal Gal residue of its precursor ... 

Figure 52-6. Diagrammatic representation of the structures of the H, A,and B blood group substances. R represents a long complex oligosaccharide chain, joined either to ceramide where the substances are glycosphingolipids, or to the polypeptide backbone of a protein via a serine or threonine residue where the substances are glycoproteins. Note that the blood group substances are biantenna ry ie, they have two arms, formed at a branch point (not indicated) between the GIcNAc—R, and only one arm of the branch is shown. Thus, the H, A,and B substances each contain two of their respective short oligosaccharide chains shown above. The AB substance contains one type A chain and one type B chain.

Amino-2-deoxy-D-galactose (D-galactosamine chondrosamine) H HO HO H HOHjC—C—C—C—C—CHO HO H H NH, frog-spawn mucin blood-group substances cartilage... 

Isolation and Characterization of a Substance from Human Ovarian Cyst Fluid of a Blood Group Substance Lacking A, B, H, Lea, and Leb Specificity, J. Immunol (1969) 102,821. 

V. A. Derevitskaya, N. P. Arbatsky, and N. K. Kochetkov, The structure of carbohydrate chains of blood-group substance. Isolation and elucidation of the structure of higher oligosaccharides from blood-group substance H, Eur. J. Biochem., 86 (1978) 423-437. 

The Presence of at Least Two Different H-Blood Group-Related /fDGal-a-2-L-Fucosyltransferases in Human Serum and the Genetics of Blood Group H Substances, J. LePendu, J. P. Cartron, R. U. Lemieux, and R. Oriol, Am. J. Hum. Genet., 37 (1985) 749-760. 

Extracts from the seeds of Laburnum alpinum were first shown to possess anti-H(O) activity by Renkonen,6 and this was confirmed by Morgan and Watkins22 and others.77,471 Although the L. alpinum lec-tin(s) has not been purified, hemagglutination-inhibition studies conducted on seed extracts reveal a specificity towards N,N -diacetylchitobiosyl residues.19,196,471 Human A, H, and neuraminidase-treated human Lea blood-group substances were also extremely good inhibitors of the Laburnum lectin.198,471... 

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