Guttman

Swain and Guttman (1983) presented a simple framework for error classification. They classified errors as ... 

Swain A. and H. Guttman 1983. Handbook of human reliability analysis with emphasis on nuclear power plant applications (NUREG/CR-1278), Nuclear Regulatory Commission, Washington, DC. 

This manager requested quantitative results, so the analyst must estimate the probability of each failure or error included in the event tree. Data for all the failures and errors in this particular problem are available in tables in the Handbook, Swain and Guttman (1983). The analyst must modify these data as necessary to account for specific characteristics of the work situation, such as stress levels, equipment design features, and interoperator dependencies. Table 5.1 summarizes the data used in this problem. 

Hydrodynamic chromatography (HdC) is a relatively new technique, especially in molecular weight separation. It was first investigated in 1969 by DiMarzio and Guttman (1,2) and was called separation by flow (3,4). Small started calling it hydrodynamic chromatography in 1974 (5). The application of this technique was first concerned with the separation of particle size. Prud homme applied it to the molecular weight separation of macromolecules in 1982 (6). 

A plot of A versus r, the calibration curve of OTHdC, is shown in Fig. 22.2. The value of constant C depends on whether the solvent/polymer is free draining (totally permeable), a solid sphere (totally nonpermeable), or in between. In the free-draining model by DiMarzio and Guttman (DG model) (3,4), C has a value of approximately 2.7, whereas in the impermeable hard sphere model by Brenner and Gaydos (BG model) (8), its value is approximately 4.89. 

Guttman M, Leger G, Reches A, et al (1993) Administration of the new COMT inhibitor OR-611 increases striatal uptake of fluorodopa. Movement Disord 8 298-304... 

This is Point s [51] equation (1), which he derived by simply postulating a net forward rate for folding, C,. We followed Di Marzio and Guttman s [143] derivation because it illustrates the way in which C, is connected both with the microscopic forward and backward rate constants. 

Guttman, A, On the Separation Mechanism of Capillary Sodium Dodecyl Sulfate-Gel Electrophoresis of Proteins, Electrophoresis 16, 611, 1995. 

If a single pore size is employed in the stationary phase, which is larger than the largest particle to be analyzed, the technique has been termed porous HDC. A model for the separation in this type of system has been described by DiMarzio and Guttman (12, 13). 

Figure 13 Separation of propranolol isomers. (From Benedek, K. and Guttman, A.,. Chromatogr., 680, 375, 1994. With permission.)...

Figure 14 Chiral separation of dansyl amino acids by chiral polyacrylamide gel electrophoresis. Peak identification 1 = dansyl-L-glutamic acid, 2 = dansyl-D-glutamic acid, 3 = dansyl-L-serine, 4 = dansyl-D-serine, 5 = dansyl-L-leucine, 6 = dansyl-D-leu-cine. (From Guttman, A., Paulus, A., Cohen, A. S., Grinberg, N. and Karger, B. L., /. Chromatogr., 448, 41, 1988. With permission.)...

Guttman, A., Novel separation scheme for capillary electrophoresis of enantiomers, Electrophoresis, 16, 1900, 1995. 

Guttman, A. and Schwartz, H. E., Artifacts related to sample introduction in capillary gel electrophoresis affecting separation performance and quantitation, Anal. Chem., 34, 2279, 1995. 

---