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Guinea pig tracheal chain

Guinea pig tracheal chain Dopaminergic Dopamine/none Domer, 1971... [Pg.754]

Guinea pig tracheal chain Histaminergic Histamine/benadryl Castillo and De Beer, 1947a, b... [Pg.754]

Castillo, J.C. and De Beer, E.J. (1947a). The guinea pig tracheal chain as an assay for histamine agonists. Fed. Proc. 6 315. [Pg.760]

For a wide variety of 6-aryl-3(2//)-pyridazinones (including those discussed in the chapter on cardiotonic agents and antithrombotics [1]), bronchodila-tor activity has been claimed in patents [104,114-116,129,423,424]. Thus, for instance, the bronchospasmolytic effects (guinea-pig tracheal-chain preparations) of compounds of type (99) have been found to exceed those of xanthines [425]. The therapeutic index of these compounds (which inhibit phosphodiesterase at lower concentrations than xanthines and do not interact with adenosine receptors) is larger than that of xanthines. [Pg.164]

Guinea Pig Tracheal Chain Test (30). A guinea pig tracheal chain prepared by modification of previously described methods (46, 47) was suspended in pH 7.3 Krebs buffer (48) aerated (95%... [Pg.253]

Definition of Terms (50). Derivation of the relative potency of N-tert-butylnorepinephrine (y) will be described to illustrate the terms and symbols used in considering structure-activity relationships among 3-adrenergic bronchodilators. This compound is an appropriate secondary standard because many of the more recent agents of this class bear a tert-butylamino substituent. In the guinea pig tracheal chain test. Id has an ED50 of 1.3 x 10 M. [Pg.254]

The bronchodilator activities of vasicine and quinazolin-4-one have been studied in detail. The activity of these compounds is in no way comparable to other known bronchodilator drugs (31). The same authors, however, failed to obtain bronchodilation with vasicinone in vivo in the guinea pig although it was observed in the isolated guinea pig tracheal chain. This difference in activity was attributed to rapid metabolism of the drug. Vasicinone was found to be less powerful than vasicine in antagonizing histamine-induced bronchospasms (cited after 124, cf. 3). [Pg.211]

Boskabady MH, Tabanfar H, Gholamnezhad Z, Sadeghnia HR (2011) Inhibitory effect of Zataria multiflora Boiss and carvacrol on histamine (H(l) ) receptors of guinea-pig tracheal chains. Fundam Clin Pharmacol. doi 10.1111/j.l472-8206.2011.00971.x... [Pg.4155]

The essential oil of R. damascena displayed a strong relaxant effect on the precontracted guinea pig tracheal chains at 0.75% and 1.0%. The effect was comparable to that of theophylline at 0.75 and 1.0 mM. ... [Pg.531]

See other pages where Guinea pig tracheal chain is mentioned: [Pg.338]    [Pg.130]    [Pg.253]    [Pg.254]    [Pg.255]    [Pg.257]    [Pg.259]    [Pg.259]    [Pg.260]    [Pg.262]    [Pg.263]    [Pg.265]    [Pg.265]    [Pg.266]    [Pg.266]    [Pg.268]    [Pg.268]    [Pg.269]    [Pg.89]    [Pg.68]    [Pg.212]    [Pg.37]    [Pg.547]   
See also in sourсe #XX -- [ Pg.253 ]



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