Guinea pig heart

Four tested compounds at 10 ° M concentration increased the contraction of guinea pig heart more effectively than amrinone (86JAP(K)1). 

Figure 4.8 Reduction of Na/K ATPase activity in isoiated guinea-pig hearts subjected to ischaemia/reperfusion and its prevention by various agents control non-ischaemic hearts (Nl) guinea-pig hearts subjected to global ischaemia for 2 h and subsequently reperfused for 1 h (IR). In other preparations, superoxide dismutase (SOD) 100 U/ml, catalase (CAT) 150 U/ml, dimethylsulphoxide (DMS) 50 mu, histidine (HIS) 10 mu, vitamin E (TOC)...

Benndorf, K., Friedrich, M. and Hirche, H. (1991). Reoxygenation-induced arrhythmogenic transient inward currents in isolated cells of the guinea-pig heart. Pflugers Arch. 418, 248-260. 

Gailis, M. and Nguyen, M.-H. (1975). The effect of sulphydryl reagents on the heart rate and coronary flow of the isolated perfused guinea pig heart. Arch. Int. Pharmacodyn. Ther. 218, 19-28. 

Hayashi, H., Miyata, H., Watanabe, H., Kobayashi A. and Yamazaki, N. (1989). Effects of hydrogen peroxide on action potentials and intracellular Ca concentration of guinea pig heart. Cardiovasc. Res. 23, 767-773. 

Hamlin, R.L., Cruze, C.A., Mittelstadt, S. W., Kijtawomrat, A., Keene, B.W., Roche, B.M., Nakayama, T., Nakayama, H., Hamlin, D.M. and Arnold, T. (2004) Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc. Journal of Pharmacological and Toxicological Methods, 49, 15—23. 

Table 3 shows pA values for practolol and propranolol against isoprenaline induced tachycardia in the guinea pig atria, relaxation of the tracheal chain, and adenylate cyclase activity of purified membrane fragments prepared from guinea pig heart and lung. While practolol is clearly cardioselective in the tissue preparations it becomes non-selective on the membrane fragments. It is conceivable that in the purification of the membranes the integrity of the micro-environment which controls access to the receptors in the different tissues, is destroyed. 

Voss, H.P., Shukrula, S., Wu, T.S., Donnell, D., and Bast, A., A functional beta-2 adrenoceptor-mediated chronotropic response in isolated guinea pig heart tissue selectivity of the potent beta-2 adrenoceptor agonist TA 2005, /. Pharmacol. Exp. Ther., 271, 386-389, 1994. 

Cardiotonic activity. Petroleum ether fraction chromatographed and fraction eluted with chloroform, administered by perfusion at a concentration of 0.20 mg/mL, was inactive on the guinea pig heart . 

Kelm, M., and Schrader, J. (1988). Nitric oxide release from the isolated guinea pig heart. Eur. J. Pharmacol. 155, 317-321. 

Imanaga I, Kameyama M, Irisawa H Cell-to-cell diffusion of fluorescent dyes in ventricular paired cells isolated from guinea pig heart. Am J Physiol 1987 252 H223-H232. 

Sugiura H, Toyama J, Tsuboi N, Kamiya K, Kodama I ATP directly affects junctional conductance between paired ventricular myocytes isolated from guinea pig heart. Circ Res 1990 66 1095—... 

The results obtained in the guinea pig heart preparations are summarized in Table 7 and in Figure 9. 

Mannaioni, P.F., Bello, M.G., Di Bello, M.G., Mirabella, C., Gai, P., Schunack, W., Masini, E., 1997. Interaction between histamine and nitric oxide in rat mast cells and in isolated guinea pig hearts. Int. Arch. Allergy Immunol. 113, 297-299. 

Antiarrhythmic effect of tetrandrine on induced arrhythmias in guinea pig heart nullified by tetrandrine 480... 

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