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Guanylyl cyclases

Receptors linked to guanylyl cyclase and which catalyze the formation of guanosine triphosphate (GMP) to guanosine-3A -cychc monophosphate (cychc GMP) include those for atrial natriuretic factor (ANF) and endothehal-derived relaxing factor (EDRF), mediating vasodilatation, and nitric oxide [10102 3-9], NO, or a clearly related derivative. [Pg.272]

Cyclic Guanosine Monophosphate Guanylyl Cyclase Nitric Oxide Carbon Monoxide... [Pg.346]

Synthesized by soluble guanylyl cyclase and particulate guanylyl cyclase from guanosine triphosphate (GTP). Nitric oxide activates soluble guanylyl cyclase to enhance cyclic GMP production that contributes to various NO actions. Cyclic GMP is hydrolyzed by phosphodiesterases. Cyclic GMP binds to and activates cGMP-dependent protein kinase, phosphodiesterases, and Cyclic Nucleotide-regulated Cation Channels. [Pg.399]

Adenylyl Cyclases Guanylyl Cyclases Transmembrane Signalling Cyclic Adenosine Monophosphate Cyclic Guanosine Monophosphate Cyclic Nucleotide-gated Channels Phosphodiesterases... [Pg.403]

Cyclic Guanosine Monophosphate Guanylyl Cyclases Smooth Muscle Tone Regulation... [Pg.558]

Guanylyl cyclases (GC) are a family of enzymes (EC 4.6.1.2) that catalyse the formation of the second messenger cyclic GMP (cGMP) from guanosine triphosphate (GTP). GCs are subdivided in soluble GCs and GCs that are membrane-bound and linked to a receptor. Activation occurs by nitric oxide (NO) and pqrtide hormones, respectively [1,2]. [Pg.572]

Friebe A, Koesling D (2003) Regulation of nitric oxide-sensitive guanylyl cyclase. Circ Res 93 96-105... [Pg.575]

Wedel BJ, Garbers DL (2001) The guanylyl cyclase family at Y2K. Annu Rev Physiol 63 215-233... [Pg.575]

Mergia E, Friebe A, Dangel O et al (2006) Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest 116 1731-1737... [Pg.575]

Heme (C34H3204N4Fe) represents an iron-porphyrin complex that has a protoporphyrin nucleus. Many important proteins contain heme as a prosthetic group. Hemoglobin is the quantitatively most important hemoprotein. Others are cytochromes (present in the mitochondria and the endoplasmic reticulum), catalase and peroxidase (that react with hydrogen peroxide), soluble guanylyl cyclase (that converts guanosine triphosphate, GTP, to the signaling molecule 3, 5 -cyclic GMP) and NO synthases. [Pg.581]

Natriuretic peptides are a family of peptide hormones. All of them contain a 17-amino acid long ring that is closed by a disulfide bond between two cysteine residues. ANP (atrial natriuretic peptide) is mainly expressed in the atria of the heart, whereas BNP (B-type natriuretic peptide) is synthesized in the ventricular myocardium. CNP occurs mainly in the endothelium and is thought to have a paracrine function. ANF and BNF lower blood pressure by a direct effect on smooth muscle and on the salt retention in the kidney. Natriuretic peptides bind and activate particulate guanylyl cyclases. [Pg.820]

Smooth Muscle Tone Regulation Guanylyl Cyclases... [Pg.855]

The enzyme guanylyl cyclase produces the second messenger guanosine monophosphate (3, 5 -cyclic GMP, cGMP) from guanosine triphosphate (GTP). [Pg.1146]

See other pages where Guanylyl cyclases is mentioned: [Pg.457]    [Pg.271]    [Pg.281]    [Pg.281]    [Pg.30]    [Pg.169]    [Pg.170]    [Pg.237]    [Pg.321]    [Pg.347]    [Pg.347]    [Pg.398]    [Pg.399]    [Pg.402]    [Pg.571]    [Pg.571]    [Pg.572]    [Pg.572]    [Pg.573]    [Pg.573]    [Pg.573]    [Pg.574]    [Pg.581]    [Pg.820]    [Pg.855]    [Pg.857]    [Pg.857]    [Pg.858]    [Pg.860]    [Pg.861]    [Pg.863]    [Pg.867]    [Pg.913]    [Pg.913]    [Pg.963]    [Pg.966]    [Pg.1145]    [Pg.1146]   
See also in sourсe #XX -- [ Pg.205 ]

See also in sourсe #XX -- [ Pg.16 ]

See also in sourсe #XX -- [ Pg.285 , Pg.443 ]



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Cyclase

Guanylyl cyclase

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