Guanosine 3 ,5 -cyclic monophosphate sodium

Figure 14 The water-to-sodium bond distances and the water-to-nucleotide hydrogen-bond distances in guanosine 3, 5 -cyclic monophosphate sodium tetrahydrate.

Cyclic phosphoric esters, especially adenosine 3, 5 -monophosphate (cAMP) and to a lesser extent guanosine 3, 5 -monophosphate (cGMP), are ubiquitous intracellular secondary messenger substances which play an important role in biochemistry. X-ray structures and NMR data have been reported and their conformations are shown in Figure 2 (see also an X-ray structural determination of the sodium salt (82JA3398)). 

B) The pattern of hydroxylation in B-rings is very important for the activity, (i) The absence or the methylation of the hydroxyl group in position 3 accounts for a lower vasodilator potency. In contrast, the lack of the 3 -hidroxyl group is related with a potentiation of the effects in the presence of sodium nitroprusside suggesting a reduced inhibitory effect on cyclic guanosine monophosphate (cGMP) PDE activity, (ii) Morin, with a... 

Reagents. Cyclic nucleotides (3, 5 -cyclic adenosine monophosphate (c-AMP), 3, 5 -cyclic guanosine monophosphate (c-GMP), and 3, 5 -cyclic inosine monophosphate (c-IMP)) sodium tetraborate hydrochloric acid and potassium hydroxide were purchased from Sigma Chemical Company, St. Louis, Missouri). Millex disposable filter units (0.22 pm) were obtained from Millipore Corporation (Bedford, Massachusetts). Triply distilled and deionized water was used for the preparation of buffer solutions. Both buffers and samples were routinely degassed with helium after filtration (using microfilter units). 

De Oliveira, J. E, Teixeira, C. E., Arantes, E. C. et al.. Relaxation of rabbit corpus cavemosum by selective activators of voltage-gated sodium channels role of nitric oxide-cyclic guanosine monophosphate pathway. Urology 62, 581, 2003. 

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