Grubbs method

Use Dixon s and Grubbs methods to test for outliers in the water hardness data in Problem 1. 

Although the metathesis of ene-ynes is a valuable method for the preparation of 1,3-butadienes, and may be used for Diels-Alder reactions, a problem arises from the need to employ either a high temperature or a Lewis add to accelerate the cycloaddition, which is usually not feasible with the Grubbs catalyst Therefore, the combination of metathesis and cycloaddition is usually performed in sequential fashion (as just shown, and highlighted earlier) [264]. However, Laschat and coworkers [265] have shown the Lewis acid BC13 to be compatible with the Grubbs I catalyst (6/3-13). Reaction of 6/3-92 and ethyl acrylate using a mixture of 2.5 equiv. of the Lewis acid and 10 mol% of 6/3-13 led to 6/3-93 in 60% yield (Scheme 6/3.27). 

The AO AC (cited in Ref. [11]) described the precision acceptance criteria at different concentrations within or between days, the details of which are provided in Table 2. Other parameters that should be tested in the precision study are the David-, Dixon- or Grubbs-, and Neumann-tests. The David-test is performed when determining whether the precision data are normally distributed. Outlier testing of the data is performed by the Dixon-test (if n < 6-8) or by the Grubbs-test (if n > 6-8), while trend testing of the data is performed by Neumann-test. Detailed methods have been described in the book written by Kromidas [29]. 

An alternative method for the preparation of polymer-chained pendant ligands has been recently developed.102 The polymerization of the (R)-hydroxylpiperidinyl fragment was realized by ROMP of a bicyclic olefin with the commercially available Grubbs catalyst. 

The procedure given above is adapted from that described by Read and Grubb.1 No other methods for the preparation of /-menthoxyacetyl chloride have been described. 

Household waste, 25 864 House-of-cards glass-ceramic microstructure, 12 635 Housewares, LLDPE, 20 207-203 Housewrap, 17 482 Housings, for cartridge filters, 11 369 Hoveya-Grubbs catalysts, 26 934 H-phosphonate DNA synthesis method, 17 624-625... 

The olefm ring-closing metathesis (RCM) has been developed into an important synthetic method which is frequently employed in many synthetic endeavors. In many applications the popular Grubbs compound 204 or advanced complexes such as 205 and 206 were used as catalysts [117]. Rutjes and co-workers [118] and Okuro and Alper [119] elegantly used oxygen-substituted allenes to prepare precursors for the... 

The most widely used catalysts for RCM are Grubbs ruthenium catalyst 9 and its second generation analogue 10, as well as first and second generation Hoveyda-Grubbs catalysts 11 and 12 (Fig. 6) [38]. The latter have superior stability and reactivity, expanding the applicability of the method considerably. Schrock molybdenum catalyst 13 has also been described for macrocy-clization [38]. 

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