Growth Hormone Electrolytes

Mechanism of Action-. An antidiarrheal and growth hormone suppressant that suppresses the secretion of serotonin and gastroenteropancreatic peptides and enhances fluid and electrolyte absorption from the G1 tract Therapeutic Effect Prolongs intestinal transit time. 

Individuals with chronic liver disease may have disorders of fluid and electrolyte balance, including ascites, edema, and effusions. Alterations of whole body potassium induced by vomiting and diarrhea, as well as severe secondary aldosteronism, may contribute to muscle weakness and can be worsened by diuretic therapy. The metabolic derangements caused by metabolism of large amounts of ethanol can result in hypoglycemia, as a result of impaired hepatic gluconeogenesis, and in ketosis, caused by excessive lipolytic factors, especially increased cortisol and growth hormone. 

Angiotensin II is an octapeptide, which was initially described as a potent vasoconstrictor agent. However, its functions have since been expanded to include regulation of cell growth, inflammation, electrolyte and water balance, hormone secretion, sympathetic nervous system activity, differentiation, and apoptosis. The discovery that it is produced both systemically and locally was instrumental in establishing a pivotal role for the peptide in several disease states, including hypertension, coronary heart disease, myocarditis, congestive heart failure, atherosclerosis, and nephrosclerosis. 

Endocrine and metabolic Blood tests Serum concentrations of pituitary horrmones (TSH, LH, FSH, ACTH, growth hormone, prolactin, vasopressin) serum concentrations of other hormones (insulin parathyroid hormone, glucagon, calcitonin, vitamin D) and serum electrolyte concentrations (sodium, potassium, calcium, magnesium)... 

Recombinant human growth hormone (hGH) is a 22-kDa protein drug having 191 amino acids. It has been used to treat a number of conditions, including short stature in children, Turner syndrome, and chronic renal failure. It is said to play an important role in the metabolism of proteins, carbohydrates, and fats as well as electrolytes and hence influences weight and height. It has been reported that hGH secretion in humans is pulsatile, showing low basal serum levels in between peaks. It has been... 

Electrolyte balance Growth hormone has an antinatriuretic action, and severe hypernatremia has been reported [17" ]. 

Effect on Electrolytes. The administration of human growth hormone raises the intracellular levels of electrolytes, leads to a loss of bone calcium, and reduces urinary levels of phosphorus, potassium, and sodium. The increase in intracellular electrolytes may result from an increase in the cellular mass. Mobilization of bone calcium leads to osteoporosis in acromegaly and calciuria. Two explanations offered for this are (1) increased glomerular filtration combined with inhibition of tubular reabsorption, and (2) stimulation of parathyroid secretion. 

Previous diagnostic evaluation had included an electroencephalogram, brain scan, and chromosomal studies, which were unremarkable. Also normal were the plasma levels of electrolytes, calcium, phosphorus, magnesium, bilirubin, thyroxine, thyroid-stimulating hormone, and growth... 

Disturbances in the electrolyte and fluid balance of the body which are tissociated with (a) persistent vomiting due to an obstructive growth, (b) vomiting due to pressure from a brain tumor, (c) diarrhea induced by hormone secreting cancers and cancer of the colon, (d) cancers which disrupt the reletise of antidiuretic hormone from the posterior pituitary, and (e) tumors causing excessive secretion of corticotropin or corticosteroid which results in hyperadrenalism. 

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