Growth Factor Expression in Neurotoxicity Mediated by Glutamate

10 Growth Factor Expression in Neurotoxicity Mediated by Glutamate 

Endogenous BDNF-TrkB signaling in glutamate-mediated neurotransmission may be involved in consolidation of information at the synapse. Recent studies also indicate that sustained synthesis of the immediate early gene Arc, activity-regulated cytoskeleton-associated protein, during glutamate toxicity protracts the 

Injections of KA also induce the expression of mRNA for cytokines such as interleukin-1/3 (IL-1/5), interleukin-6, tumor necrosis factor (TlMF-a), and leukemia inhibitory factor in different regions of rat brain (Minami et al., 1991 Yabuuchi et al., 1993). Cytokines play important roles not only in neurodegeneration, but also 

6 Glutamate Receptors and Other Neurochemical Parameters in Excitotoxicity 

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