Group decane samples

Table 6.11 illustrates a representative buspirone metabolite structure database. Information on the structure, molecular weight, UV characteristics, RRT, and product ions of metabolites obtained from rat bile, urine, and liver S9 samples are compiled. Using this format, the predominant buspirone metabolite profile groups, As-B-P, A-B-Ps, and As-B-Ps are easily recognized. These profile groups indicate azaspirone decane dione and pyrimidine as metabolically active sites of attack and the presence of multiple substitution sites on each of these substructures. In many cases, the profile groups indicate the occurrence of metabolic reactions on more than one substructure. 

Fig. 10-1. Linear dependence of log K" and R on the number of groups i of a particular type in the sample molecule [Eqs. (10-4) and (IO-4a)]. (a) Adsorption of aromatic hydrocarbons on 1.9% H2O-AUO3 from pentane (S), n equals number of aromatic carbon atoms (b) adsorption of aromatic hydrocarbons on 1.0% HjO-Florisil from pentane (9), n equals number of aromatic carbon atoms (c) adsorption of fatty acids on charcoal from ethanol (10), n equals number of aliphatic carbon atoms (d) adsorption of methyl ester-substituted porphyrins on silica from decane-chloroform (II), n equals number of —COOCH3 groups.

The presence of the polar groups introduces another factor capable to enhance the aggregation numbers for the zwitterionic samples in n-decane. Much lower Nw values were observed for the amine-capped copolymers, meaning that the amine groups are not polar enough to enhance the association process. Typical LALLS plots are given in figure 12. 

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