Griseofulvin Theophylline

Examples of solvent-mediated transformation monitoring include the conversion of anhydrous citric acid to the monohydrate form in water [235,236], CBZ with water [237] and ethanol-water mixtures [238,239], and cocrystallization studies of CBZ, caffeine, and theophylline with water [240]. Raman spectroscopy was used to monitor the crystallization rate and solute and solvent concentrations as griseofulvin was removed from an acetone solution using supercritical CO2 as an antisolvent [241]. Progesterone s crystallization profile was monitored as antisolvent was added [242]. 

Drugs that may affect barbiturates include alcohol, charcoal, chloramphenicol, MAO inhibitors, rifampin, and valproic acid. Drugs that may be affected by barbiturates include acetaminophen, anticoagulants, beta blockers, carbamazepine, chloramphenicol, clonazepam, oral contraceptives, corticosteroids, digitoxin, doxorubicin, doxycycline, felodipine, fenoprofen, griseofulvin, hydantoins, methoxyflurane, metronidazole, narcotics, phenmetrazine, phenylbutazone, quinidine, theophylline, and verapamil. 

GRISEOFULVIN BRONCHODILATORS -THEOPHYLLINE t theophylline levels Inhibition of metabolism of theophylline Uncertain clinical significance. Watch for early features of theophylline toxicity... 

Extracted acetaminophen, allobarbital, azinphos, barbital, brallobarbitone, bromazepam, butethal, caffeine, carbaryl, cephaloridine, chloramphenicol, chlordiazepoxide, chlorothiazide, chlorvinphos, clothiapine, cocaine, coomassie blue, desipramine, diazepam, diphenhydramine, dipipanone, ethylbromphos, flufenamic acid, formothion, griseofulvin, indo-methacin, lidocaine, lorazepam, malathion, medazepam, midazolam, oxazepam, paraoxon, penicillin G, pentobarbital, prazepam, propoxyphene, prothiophos, quinine, salicylic acid, secobarbital, strychnine, sulfamethoxazole, theophylline, thiopental, thioridazine, trimethoprim... 

Griseofulvin does not appear to alter the pharmacokinetics of theophylline to a clinically relevant extent. 

A study was initiated because it was suspected that griseofulvin might possibly interact with theophylline. In 12 healthy subjects griseofulvin 500 mg daily for 8 days reduced the half-life of theophylline from 6.6 to 5.7 hours, and increased the clearance of two of its metabolites, after a single oral dose of aminophylline (Teojylamiri). However, these changes are far too small to usually have any clinical relevance. There would appear to be no reason for avoiding concurrent use. 

Rasmussen BB, Jeppesen U, Gaist D, Brosen K. Griseofulvin and fluvoxamine interactions with the metabolism of theophylline. Ther Drug Monit Q.991) 19, 56-62. 

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