Griseofulvin solid dispersions

WY Lo, SL Law. Dissolution behavior of griseofulvin solid dispersions using polyethylene glycol, talc, and their combination as dispersion carriers. Drug Dev Ind Pharm 1996 22 231-236. 

Chiou WL, Riegelman S. Preparation and dissolution characteristics of several fast-release solid dispersions of griseofulvin. J Pharm Sci 1969 58 1505-1510. 

Alden, M., J. Tegenfeldt, and E. S. Evan. 1993. Structures formed by interactions in solid dispersions of the system polyethylene gycol-griseofulvin with charged and noncharged surfactantsMklfedPharm. 94 31-38. 

Tg values of dextran-rich phase when compared neat dextran (inset). The solid solubility of trehalose was determined to be at 12% w/w sftCS/05% RH conditions. In another study, changes in thfFg of griseofulvin-PVP and indoprofen-PVP solid dispersions were measured for up to 3 months by storing them at 40/70% RH conditions (Figure 18.13). While griseofulvin-PVP... 

Chiou, W. L. 1977. Pharmaceutical applications of solid dispersions X-ray diffraction and aqueous solubility studies on griseofulvin-poly(ethylene glycol) 6000 systeuhrBharm Sc66 989-991. 

Chiou, W.L. Riegelman, S. Oral absorption of griseofulvin in dogs increased absorption via solid dispersion in polyethylene Glycol 6000. J. Pharm. Sci. 1970, 59, 937-942. 

Several examples of in vivo performance of solid dispersions have been published. The in vivo performance of solid dispersion systems containing sulfathiazole-urea, chloramphenicol-urea, reserpine-bile acids, and griseofulvin-PEGs were reviewed by Chiou and Riegelman.P Some other representative examples are summarized below ... 

Fig. 37.15 Dissolution of griseofulvin-succinic acid preparations in water at 37°C. Black symbols denote melt-products, hollow symbols plain griseofulvin or physical mixtures, respectively. Circles, solid dispersion and physical mixture, composition S (see phase diagram Fig. 37.9) triangles, eutectic solid dispersion and physical mixture, composition E squares, crystalline griseofulvin diamonds, micronized griseofulvin. Redrawn from Goldberg et...

Chiou WL, Riegelman S (1969) Preparation and dissolution characteristics of several fast-release solid dispersions of griseofulvin. J Pharm Sci 58(12) 1505-1510 Chiou WL, Riegelman S (1971) Pharmaceutical applications of solid dispersion systems. J Pharm Sci60(9) 1281-1302... 

Mahieu A, WiUart J-F et al (2013b) On the polymorphism of griseofulvin identification of two additional polymorphs. J Pharm Sd 102 462- 68 Marsac PJ, Li T et al (2009) Estimation of drug-polymer miscibility and solubihty in amorphous solid dispersions using experimentally determined interaction parameters, vol 26. Springer, pp 139-151... 

C. Flego, M. Lovrecich and E Rubessa, Dissolution rate of griseofulvin from solid dispersions with poly(vinylmethylether/maleic anhydride) . Drug Dev. Ind. Pharm., vol. 14, no. 9, pp. 1185-1202, 1988. 

Chiou and Riegelman reviewed the pharmaceutical applications of solid dispersion systems. These authors found complete and rapid absorption of griseofulvin dispersed in polyethylene glycol 6000 for both capsule and tablet dosage forms, in contrast to irregular and incomplete absorption from commercially available micronized drug. Munzel reviewed various formulation variables which can influence drug action. Kakemi and co-workers studied the effects of buffer components, osmotic... 

The combination of solid-state ATR-IR and solid-state NMR data supported the conclusion that the presence of crystalline material was responsible for changes in the dissolution profiles of the different lots. The results appear consistent with historical examples of changes in API physical form of solid, high molecular weight, polyethylene glycol dispersion formulations of amorphous indomethacin and griseofulvin (92-95). 

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