Grape products, resveratrol

The anti-carcinogenic effects of resveratrol were also tested in vivo, by examination of mammary glands of mice treated with DMBA and TPA. A dose-dependent reduction in the formation of tumors was observed when the mice were treated with resveratrol. Resveratrol is present in high concentrations in the skins of grapes (50-100 pg/g) and, consequently, in red wine (1.5-3 mg/1). Based on these experiments, the consumption of grapes and grape products appears to have beneficial effects. 

Resveratrol and piceid are mainly present in grape and grape products, and its composition is affected by grape variety, maturity degree at harvest, fungal... 

Resveratrol is a well known stilbene that exerts health benefits when consumed as grapes or grape products, primarily due to antioxidant activity [60-61]. 

Resveratrol is another type of polyphenol, a stilbene derivative, that has assumed greater relevance in recent years as a constituent of grapes and wine, as well as other food products, with antioxidant, anti-inflammatory, anti-platelet, and cancer preventative properties. Coupled with the cardiovascular benefits of moderate amounts of alcohol, and the beneficial antioxidant effects of flavonoids, red wine has now emerged as an unlikely but most acceptable medicinal agent. 

G., Moon, R. C., and Pezzuto, J. M., 1997, Cancer chemopreventive activity of resveratrol, a natural product derived lfom grapes, Science 275 218-220. 

Lu R, Serrero G. 1999. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J. Cell Physiol 179 297-304. 

Clement MV, Hirpara JL, Chawdhury SH, Pervaiz S. 1998. Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood 92 996-1002. 

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