Granulocyte phagocytosis

An acetylated triterpene saponin, isolated together with jenisseensosides C and D from the roots of Silene fortunei, enhances granulocyte phagocytosis in... 

Root, R. K., Metcalf, J., Oshino, N., Chance, B. (1975). H202 release from human granulocytes during phagocytosis. J. Clin. Invest. 55, 945-55. 

Cline, M. J. (1966). Phagocytosis and synthesis of ribonucleic acid in human granulocytes. Nature 212,1431-3. 

Colchicine does not influence the renal excretion of uric acid or its concentration in blood. By virtue of its ability to bind to tubulin, colchicine interferes with the function of the mitotic spindles and causes depolymerization and disappearance of the fibrillar microtubules in granulocytes and other motile cells. This action is apparently the basis for the beneficial effect of colchicine, namely, the inhibition of the migration of granulocytes into the inflamed area and a decreased metabolic and phagocytic activity of granulocytes. This reduces the release of lactic acid and proinflammatory enzymes that occurs during phagocytosis and breaks the cycle that leads to the inflammatory response. 

Non-specific cellular immunity All other immune cell types such as granulocytes, various cells of the mononuclear phagocytosis system (macrophages/ monocytes, dendritic cells) or natural killer cells form part of the (less specialized) innate immunity. 

B24. Brandt, L., and Hedberg, H., Impaired phagocytosis by peripheral blood granulocytes in systemic lupus erythematosus. Scand. J. Haematol. 6,348—353 (1969). 

Erhard, M., Kellner, J., Wild, J., Losch, U., and Hatiboglu, F.S. 1994. Effect of Echinacea aconitum, lachesis and apis extracts, their combinations on phagocytosis of human granulocytes. PTR, Phytother. Res. 8, 14-17. 

---