Granule bond formation bonding

When evaluating the effect of binder concentration on a number of tablet properties, surface area measurements were used to investigate the bond strength of the binder with the other particles [18]. A steady reduction in the surface area of the granules with increasing binder concentration indicated that the binder had covered or penetrated the particles, with the formation of particle-binder bonds. This was related to friability, and the increased bond strength was related to the decreased surface areas. 

During the transition of the mature keratinocyte into the corneocyte, profilaggrin that is released from the keratohyalin granules is dephosphorylated and proteolytically processed to filaggrin monomers. Filaggrin is responsible for the formation of extensive disulfide bonds... 

In contrast to the usual blending of cellulose via a solution medium, a fine-powdered composition was obtained by ball-milling a dry mixture of fibrous cellulose and granulated PEG without any solvent [63]. A certain extent of compatibilization of PEG with cellulose appears to occur even in their solid state, probably by insertion of parts of PEG molecules into the cellulose domains, followed by the formation of hydrogen bonds between cellulose hydroxyls and polyether oxygens. It was shown that such a mechano-chemically prepared powder was moldable three-dimensionally by facile hot-press treatment, e.g., at 120 °C for a composition of CELL/PEG = 80/20 (wt/wt) [64],... 

Stanley-Wood, N.G. Shubair, M.S. The influence of binder concentration on the bond formation of pharmaceutical granules. J. Pharm. Pharmacol. 1979, 31, 429 33. 

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